Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.56 |
| ▸ | CA2 | P00918 | 2/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | CA4 | P22748 | 6/20 | 0.55 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LDHA | P00338 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL7997152 | 1.00 | CA1 (0.56) | CA1CA2CA9CA4FAHD1 | |
| Bicarbonate SCHEMBL9135671 | 1.00 | CA1 (0.56) | CA1CA2CA9CA4FAHD1 | |
| Bicarbonate SCHEMBL11307248 | 1.00 | CA1 (0.56) | CA1CA2CA9CA4FAHD1 | |
| Bicarbonate SCHEMBL285297 | 1.00 | CA1 (0.56) | CA1CA2CA9CA4FAHD1 | |
| Bicarbonate SCHEMBL15420047 | 1.00 | CA1 (0.56) | CA1CA2CA9CA4FAHD1 | |
| Bicarbonate SCHEMBL11316678 | 1.00 | CA1 (0.56) | CA1CA2CA9CA4FAHD1 | |
| Bicarbonate SCHEMBL7504887 | 1.00 | CA1 (0.56) | CA1CA2CA9CA4FAHD1 | |
| Bicarbonate SCHEMBL19347055 | 1.00 | CA1 (0.56) | CA1CA2CA9CA4FAHD1 | |
| Bicarbonate SCHEMBL9481330 | 1.00 | CA1 (0.56) | CA1CA2CA9CA4FAHD1 | |
| Bicarbonate SCHEMBL10592361 | 1.00 | CA1 (0.56) | CA1CA2CA9CA4FAHD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3397761-A1 | ENZYME VARIANTS AND POLYNUCLEOTIDES ENCODING THE SAME | Novozymes A/S (DK) | 2018-11-07 | — | — | EP | disclosed |
| WO-2017114891-A1 | ENZYME VARIANTS AND POLYNUCLEOTIDES ENCODING THE SAME | NOVOZYMES A/S (DK) | 2017-07-06 | — | — | WO | disclosed |
| CN-101932703-B | There is the alpha-amylase variants of the characteristic of change | DANISCO US INC. (US) | 2015-08-05 | — | — | CN | disclosed |
| CN-101848986-B | Alpha-amylase variants with altered properties | DANISCO US INC | 2014-12-03 | — | — | CN | disclosed |
| CN-101848985-B | Variants of bacillus sp. TS-23 alpha-amylase with altered properties | DANISCO US INC | 2014-12-03 | — | — | CN | disclosed |
| CN-101974375-B | Subtilase variants having an improved wash performance on egg stains | NOVOZYMES AS | 2014-07-02 | — | — | CN | disclosed |
| CN-101970634-B | Ts23 alpha-amylase variants with altered propertie | DANISCO US INC | 2014-01-22 | — | — | CN | disclosed |
| EP-2534233-A2 | CLEANING COMPOSITION COMPRISING AMYLASE VARIANTS WITH HIGH STABILITY IN THE PRESENCE OF A CHELATING AGENT | The Procter & Gamble Company (US) | 2012-12-19 | — | — | EP | disclosed |
| EP-2414514-A2 | COMPOSITIONS AND METHODS COMPRISING ALPHA-AMYLASE VARIANTS WITH ALTERED PROPERTIES | Danisco US Inc. (US) | 2012-02-08 | — | — | EP | disclosed |
| EP-2414515-A2 | CLEANING SYSTEM COMPRISING AN ALPHA-AMYLASE AND A PROTEASE | Danisco US Inc. (US) | 2012-02-08 | — | — | EP | disclosed |
| EP-1272623-A2 | NOVEL SUBTILASE ENZYMES HAVING AN IMPROVED WASH PERFORMANCE ON EGG STAINS | Novozymes A/S (DK) | 2003-01-08 | — | — | EP | disclosed |
| WO-2002031133-A1 | SUBTILASE VARIANTS | NOVOZYMES A/S (DK) | 2002-04-18 | — | — | WO | disclosed |
| EP-1173554-A2 | POLYPEPTIDES HAVING ALKALINE ALPHA-AMYLASE ACTIVITY AND NUCLEIC ACIDS ENCODING SAME | Novozymes A/S (DK) | 2002-01-23 | — | — | EP | disclosed |
| WO-2001068821-A2 | NOVEL SUBTILASE ENZYMES HAVING AN IMPROVED WASH PERFORMANCE ON EGG STAINS | NOVOZYMES A/S (DK) | 2001-09-20 | — | — | WO | disclosed |
| WO-2000060060-A2 | POLYPEPTIDES HAVING ALKALINE ALPHA-AMYLASE ACTIVITY AND NUCLEIC ACIDS ENCODING SAME | NOVOZYMES A/S (DK) | 2000-10-12 | — | — | WO | disclosed |
| EP-0910631-A2 | ENZYME-CONTAINING GRANULES AND PROCESS FOR THE PRODUCTION THEREOF | NOVO NORDISK A/S (DK) | 1999-04-28 | — | — | EP | disclosed |
| EP-0851913-A1 | NOVEL LIPOLYTIC ENZYMES | NOVO NORDISK A/S (DK) | 1998-07-08 | — | — | EP | disclosed |
| WO-1997039116-A1 | ENZYME-CONTAINING GRANULES AND PROCESS FOR THE PRODUCTION THEREOF | NOVO NORDISK A/S (DK) | 1997-10-23 | — | — | WO | disclosed |
| WO-1997007202-A1 | NOVEL LIPOLYTIC ENZYMES | NOVO NORDISK A/S (DK) | 1997-02-27 | — | — | WO | disclosed |
| WO-1997004078-A1 | A MODIFIED ENZYME WITH LIPOLYTIC ACTIVITY | NOVO NORDISK A/S (DK) | 1997-02-06 | — | — | WO | disclosed |