⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19645307 | 1.00 | — | — | |
| SCHEMBL5351420 | 1.00 | — | — | |
| SCHEMBL13889160 | 1.00 | — | — | |
| SCHEMBL1672698 | 1.00 | — | — | |
| SCHEMBL191998 | 1.00 | — | — | |
| SCHEMBL1983990 | 1.00 | CYP2C9 (0.39) | — | |
| SCHEMBL36515 | 1.00 | — | — | |
| SCHEMBL351728 | 1.00 | — | — | |
| Water SCHEMBL227534 | 0.94 | LMNA (0.37) | — | |
| Cyclopropane SCHEMBL483844 | 0.89 | TSHR (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 180 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114981436-A | Novel TLR9 agonists | SBI生物技术有限公司 | 2022-08-30 | — | — | CN | claimed |
| CN-104278037-B | Immunomodulatory oligonucleotide (IRO) compounds for modulating Toll-like receptors based on variant response | 艾德拉药物股份有限公司 | 2020-09-15 | — | — | CN | claimed |
| EP-2437791-B1 | POTENTIATION OF AUTOIMMUNE AND INFLAMMATORY DISEASE TREATMENTS BY IMMUNE REGULATORY OLIGONUCLEOTIDE (IRO) ANTAGONISTS OF TLR7 AND TLR9 | IDERA PHARMACEUTICALS INC (US) | 2017-03-22 | — | — | EP | claimed |
| US-9206430-B2 | Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response | IDERA PHARMACEUTICALS, INC. (US) | 2015-12-08 | — | — | US | claimed |
| EP-2343307-B1 | Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response | IDERA PHARMACEUTICALS (US) | 2015-08-05 | — | — | EP | claimed |
| US-8987221-B2 | Potentiation of autoimmune and inflammatory disease treatments by immune regulatory oligonucleotide (IRO) antagonists of TLR7 and TLR9 | IDERA PHARMACEUTICALS, INC. (US) | 2015-03-24 | — | — | US | claimed |
| US-8853177-B2 | Use of inhibitors of toll-like receptors in the prevention and treatment of hypercholesterolemia and hyperlipidemia and diseases related thereto | IDERA PHARMACEUTICALS, INC. (US) | 2014-10-07 | — | — | US | claimed |
| US-20130267583-A1 | IMMUNE REGULATORY OLIGONUCLEOTIDE (IRO) COMPOUNDS TO MODULATE TOLL-LIKE RECEPTOR BASED IMMUNE RESPONSE | IDERA PHARMACEUTICALS, INC. (US) | 2013-10-10 | — | — | US | claimed |
| US-8426375-B2 | Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response | IDERA PHARMACEUTICALS, INC. (US) | 2013-04-23 | — | — | US | claimed |
| US-8399423-B2 | Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response | IDERA PHARMACEUTICALS, INC. (US) | 2013-03-19 | — | — | US | claimed |
| US-8377898-B2 | Antisense oligonucleotides for prevention and/or treatment of infection, asthma, skin, inflammatory and/or autoimmune disorders | IDERA PHARMACEUTICALS, INC. (US) | 2013-02-19 | — | — | US | claimed |
| US-8357665-B2 | Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response | IDERA PHARMACEUTICALS, INC. (US) | 2013-01-22 | — | — | US | claimed |
| EP-2451974-A2 | OLIGONUCLEOTIDE-BASED COMPOUNDS AS INHIBITORS OF TOLL-LIKE RECEPTORS | Idera Pharmaceuticals, Inc. (US) | 2012-05-16 | — | — | EP | claimed |
| EP-2343307-A1 | Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response | Idera Pharmaceuticals (US) | 2011-07-13 | — | — | EP | claimed |
| US-20110009477-A1 | OLIGONUCLEOTIDE-BASED COMPOUNDS AS INHIBITORS OF TOLL-LIKE RECEPTORS | IDERA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | US | claimed |
| WO-2011005942-A2 | OLIGONUCLEOTIDE-BASED COMPOUNDS AS INHIBITORS OF TOLL-LIKE RECEPTORS | IDERA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | claimed |
| EP-1094060-A2 | New process for the preparation of retiferol derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-25 | — | — | EP | claimed |
| EP-0154225-B1 | PROCESS FOR THE PREPARATION OF AN OPTICALLY ACTIVE LACTONE, AND INTERMEDIATES IN THE PROCESS | F. HOFFMANN-LA ROCHE AG (CH) | 1991-04-03 | — | — | EP | claimed |
| US-4636566-A | Process for preparing D-(+)-biotin and intermediates therefor | HOFFMANN-LA ROCHE INC. (US) | 1987-01-13 | — | — | US | claimed |
| EP-0154225-A2 | Process for the preparation of an optically active lactone, and intermediates in the process | F. HOFFMANN-LA ROCHE AG (CH) | 1985-09-11 | — | — | EP | claimed |