Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.73 |
| ▸ | HPGD | P15428 | 3/20 | 0.73 |
| ▸ | HTT | P42858 | 3/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.73 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.68 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
| ▸ | EEF2K | O00418 | 10/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.48 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL429207 | 0.84 | ALDH1A1 (1.00) | ALDH1A1HPGDHTTTDP1LMNA | |
| SCHEMBL13941637 | 0.82 | ALDH1A1 (0.96) | ALDH1A1HPGDHTTTDP1LMNA | |
| SCHEMBL13392917 | 0.79 | ALDH1A1 (0.81) | ALDH1A1HPGDHTTTDP1LMNA | |
| SCHEMBL3166845 | 0.78 | ALDH1A1 (0.79) | ALDH1A1HPGDHTTTDP1LMNA | |
| SCHEMBL13393359 | 0.77 | ALDH1A1 (0.78) | ALDH1A1HPGDHTTTDP1LMNA | |
| SCHEMBL13392961 | 0.76 | ALDH1A1 (0.74) | ALDH1A1HPGDHTTTDP1LMNA | |
| SCHEMBL13392945 | 0.75 | ALDH1A1 (0.73) | ALDH1A1HPGDHTTTDP1LMNA | |
| SCHEMBL5742051 | 0.74 | HPGD (0.54) | ALDH1A1HPGDTDP1NPSR1KDM4E | |
| SCHEMBL429444 | 0.74 | ALDH1A1 (0.70) | ALDH1A1HPGDHTTTDP1LMNA | |
| SCHEMBL1320409 | 0.72 | HPGD (0.56) | ALDH1A1HPGDHTTTDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773840-B1 | SUBSTITUTED PYRIDO[3',2':4,5]THIENO[3,2-D]PYRIMIDINES AND PYRIDO[3',2':4,5]FURO[3,2-D]-PYRIMIDINES FOR USE AS INHIBITORS OF PDA-4 AND/OR TNF-ALPHA RELEASE | MEDICINES CO LEIPZIG GMBH (DE) | 2010-01-20 | — | — | EP | disclosed |
| EP-1773840-A1 | SUBSTITUTED PYRIDO[3',2':4,5]THIENO[3,2-D]PYRIMIDINES AND PYRIDO[3',2':4,5]FURO[3,2-D]-PYRIMIDINES FOR USE AS INHIBITORS OF PDA-4 AND/OR TNF-ALPHA RELEASE | Curacyte Discovery GmbH (DE) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006010567-A1 | SUBSTITUTED PYRIDO[3', 2': 4, 5]THIENO[3,2-D]PYRIMIDINES AND PYRIDO[3', 2': 4, 5]FURO[3, 2, D]PYRIMIDINES USED AS INHIBITORS OF THE PDE-4 AND/OR THE RELEASE OF TNF$G(A) | CURACYTE DISCOVERY GMBH (DE) | 2006-02-02 | — | — | WO | disclosed |