SCHEMBL28530395

SCHEMBL28530395

Brc1cccc2nc(I)nn12

nearest known ligand 0.54

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
AHR P35869 2/20 0.54
CYP11B2 P19099 1/20 0.36
JAK2 O60674 1/20 0.34
JAK3 P52333 1/20 0.34
PTK2 Q05397 1/20 0.34
NUDT1 P36639 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3303841 0.79 AHR (0.58) AHRCYP11B2NUDT1
SCHEMBL13457590 0.78 AHR (0.56) AHRCYP11B2NUDT1
SCHEMBL45713 0.76 NUDT1 (0.56) AHRCYP11B2JAK3NUDT1
SCHEMBL18366725 0.72 PDE10A (0.44)
SCHEMBL18366669 0.72 NUDT1 (0.65) JAK2JAK3PTK2NUDT1
SCHEMBL16439318 0.72 AHR (0.50) AHRCYP11B2JAK2JAK3PTK2
SCHEMBL30676207 0.72 AHR (0.78) AHRCYP11B2NUDT1
SCHEMBL30601204 0.71 AHR (1.00) AHRCYP11B2
SCHEMBL18341116 0.71 AHR (0.49) AHRCYP11B2NUDT1
SCHEMBL28485655 0.69 AHR (0.47) AHRCYP11B2PTK2NUDT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118108717-A Organic compound and application thereof, and organic electroluminescent device comprising organic compound 北京鼎材科技有限公司 2024-05-31 CN disclosed
CN-107759587-B [1,2,4] triazolo [1,5-a ] pyridine compound and preparation method and medical application thereof 中国医药研究开发中心有限公司 2021-01-26 CN disclosed