SCHEMBL28530787

SCHEMBL28530787

C1=CCOC=C1.Nc1ccccc1N

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 2/20 0.43
CYP3A4 P08684 2/20 0.43
CASP1 P29466 1/20 0.43
CASP7 P55210 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
L3MBTL1 Q9Y468 2/20 0.33
ALDH1A1 P00352 1/20 0.33
TSHR P16473 2/20 0.31
MEN1 O00255 1/20 0.30
MAPT P10636 1/20 0.30
KMT2A Q03164 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30
APOBEC3G Q9HC16 1/20 0.30
NPC1 O15118 1/20 0.30
GAA P10253 1/20 0.30
RAB9A P51151 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Triphenylene SCHEMBL5429154 0.82 KDM4E (0.30) CYP3A4CASP1CASP7SMN1; SMN2ALDH1A1
Naphthalene SCHEMBL27561595 0.82 CYP2A6 (0.38)
Biphenyl SCHEMBL27460490 0.80 ALDH1A1 (0.41) CYP3A4SMN1; SMN2ALDH1A1NPC1RAB9A
Anthracene SCHEMBL27342982 0.78 ALDH1A1 (0.32) ALOX15CYP3A4CASP1CASP7ALDH1A1
Benzene SCHEMBL27406391 0.78
SCHEMBL1956229 0.78
SCHEMBL11025 0.78
SCHEMBL27966808 0.78
Toluene SCHEMBL28621404 0.77 LMNA (0.46) SMN1; SMN2TSHRNPC1RAB9A
Hydroxyamine SCHEMBL28563497 0.76

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112341446-B Immunomodulator 成都先导药物开发股份有限公司 2022-06-17 CN disclosed
CN-112341446-A Immunomodulator 成都先导药物开发股份有限公司 2021-02-09 CN disclosed