Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PADI4 | Q9UM07 | 18/20 | 0.58 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28529826 | 0.99 | PADI4 (0.57) | PADI4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL30325275 | 0.86 | PADI4 (0.52) | PADI4PTGER4 | |
| SCHEMBL25145104 | 0.86 | PADI4 (0.52) | PADI4PTGER4 | |
| Hydrochloric Acid SCHEMBL28524626 | 0.85 | PADI4 (0.53) | PADI4PTGER4 | |
| Hydrochloric Acid SCHEMBL30325573 | 0.85 | PADI4 (0.53) | PADI4PTGER4 | |
| SCHEMBL28539904 | 0.83 | LMNA (0.47) | PADI4BRD4 | |
| SCHEMBL28539969 | 0.82 | PADI4 (0.61) | PADI4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL18247356 | 0.82 | PADI4 (0.69) | PADI4PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL28561906 | 0.82 | PADI4 (0.45) | PADI4 | |
| SCHEMBL28539017 | 0.82 | KMT2A (0.44) | PADI4PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107849015-B | Benzimidazole derivatives as PAD4 inhibitors | 葛兰素知识产权发展有限公司 | 2021-03-19 | — | — | CN | claimed |
| CN-107849015-B | Benzimidazole derivatives as PAD4 inhibitors | 葛兰素知识产权发展有限公司 | 2021-03-19 | — | — | CN | disclosed |