Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19151419 | 0.84 | SMN1; SMN2 (0.53) | SMN1; SMN2TDP1ALDH1A1RAB9ANPC1 | |
| SCHEMBL10665125 | 0.83 | RAB9A (0.66) | SMN1; SMN2MAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL16943227 | 0.82 | KDM4E (0.62) | SMN1; SMN2LMNAALDH1A1KDM4EKMT2A | |
| SCHEMBL19116581 | 0.80 | SMN1; SMN2 (0.81) | SMN1; SMN2LMNAHTTMAPTALDH1A1 | |
| SCHEMBL19116524 | 0.80 | ADORA1 (0.51) | SMN1; SMN2HTTMAPTALDH1A1KDM4E | |
| SCHEMBL13071962 | 0.80 | SMN1; SMN2 (0.49) | SMN1; SMN2TDP1LMNAHTTMAPT | |
| SCHEMBL11964356 | 0.76 | TDP1 (0.46) | SMN1; SMN2TDP1LMNAHTTALDH1A1 | |
| SCHEMBL10463825 | 0.74 | NR3C2 (0.44) | SMN1; SMN2TDP1LMNAALDH1A1KDM4E | |
| SCHEMBL19718960 | 0.74 | ADORA1 (0.48) | SMN1; SMN2LMNAKDM4EKMT2AMEN1 | |
| SCHEMBL9689348 | 0.74 | GAA (0.79) | SMN1; SMN2TDP1LMNAHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113105411-B | Hydrazone amide derivatives and pharmaceutical compositions | 深圳市三启药物开发有限公司 | 2023-03-17 | — | — | CN | disclosed |
| CN-113105411-A | Hydrazone amide derivatives and pharmaceutical compositions | 深圳市三启药物开发有限公司 | 2021-07-13 | — | — | CN | disclosed |
| CN-110330465-B | Hydrazone amide derivative and application thereof in preparation of alopecia prevention and treatment medicines | 深圳市三启药物开发有限公司 | 2021-05-11 | — | — | CN | disclosed |
| CN-110229118-B | Hydrazone amide derivative and application thereof in preparation of anti-osteoporosis drugs | 深圳市三启药物开发有限公司 | 2021-03-02 | — | — | CN | disclosed |