Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 6/20 | 0.70 |
| ▸ | TSHR | P16473 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | KDM5A | P29375 | 1/20 | 0.44 |
| ▸ | KDM5C | P41229 | 1/20 | 0.44 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.44 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 6/20 | 0.44 |
| ▸ | PPARG | P37231 | 6/20 | 0.44 |
| ▸ | PPARD | Q03181 | 6/20 | 0.44 |
| ▸ | PPARA | Q07869 | 6/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.44 |
| ▸ | TLR2 | O60603 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | FABP4 | P15090 | 2/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.44 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.44 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL27740164 | 0.97 | DNM1 (0.75) | DNM1TSHRALDH1A1GPR84PPARG | |
| Bicarbonate SCHEMBL28289848 | 0.97 | DNM1 (0.75) | DNM1TSHRALDH1A1GPR84PPARG | |
| Bicarbonate SCHEMBL27740162 | 0.97 | DNM1 (0.75) | DNM1TSHRALDH1A1GPR84PPARG | |
| Bicarbonate SCHEMBL4389120 | 0.97 | DNM1 (0.75) | DNM1TSHRALDH1A1GPR84PPARG | |
| Bicarbonate SCHEMBL4389117 | 0.97 | DNM1 (0.75) | DNM1TSHRALDH1A1GPR84PPARG | |
| Bicarbonate SCHEMBL27083091 | 0.97 | DNM1 (0.75) | DNM1TSHRALDH1A1GPR84PPARG | |
| Bicarbonate SCHEMBL1689392 | 0.97 | DNM1 (0.75) | DNM1TSHRALDH1A1GPR84PPARG | |
| Bicarbonate SCHEMBL414156 | 0.97 | DNM1 (0.75) | DNM1TSHRALDH1A1GPR84PPARG | |
| Bicarbonate SCHEMBL30524909 | 0.97 | DNM1 (0.75) | DNM1TSHRALDH1A1GPR84PPARG | |
| Dymanthine SCHEMBL27918138 | 0.97 | DNM1 (0.75) | DNM1TSHRALDH1A1GPR84PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108201773-B | Method for absorbing volatile organic compounds in gas by using hydrophilic switchable reversible solvent | 昆明理工大学 | 2021-03-02 | — | — | CN | disclosed |
| CN-108201773-A | A kind of method that volatile organic matter in reversible solvent absorption gas can be switched using hydrophily | 昆明理工大学 | 2018-06-26 | — | — | CN | disclosed |