Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 6/20 | 0.75 |
| ▸ | TSHR | P16473 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.48 |
| ▸ | PPARG | P37231 | 7/20 | 0.48 |
| ▸ | PPARD | Q03181 | 7/20 | 0.48 |
| ▸ | PPARA | Q07869 | 7/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.48 |
| ▸ | TLR2 | O60603 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | FABP4 | P15090 | 2/20 | 0.48 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.48 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL27083091 | 1.00 | DNM1 (0.75) | DNM1TSHRALDH1A1GPR84PPARG | |
| Bicarbonate SCHEMBL30524909 | 1.00 | DNM1 (0.75) | DNM1TSHRALDH1A1GPR84PPARG | |
| Dymanthine SCHEMBL27918138 | 1.00 | DNM1 (0.75) | DNM1TSHRALDH1A1GPR84PPARG | |
| Bicarbonate SCHEMBL28289848 | 1.00 | DNM1 (0.75) | DNM1TSHRALDH1A1GPR84PPARG | |
| Bicarbonate SCHEMBL414156 | 1.00 | DNM1 (0.75) | DNM1TSHRALDH1A1GPR84PPARG | |
| Bicarbonate SCHEMBL4389117 | 1.00 | DNM1 (0.75) | DNM1TSHRALDH1A1GPR84PPARG | |
| Bicarbonate SCHEMBL27740162 | 1.00 | DNM1 (0.75) | DNM1TSHRALDH1A1GPR84PPARG | |
| Bicarbonate SCHEMBL27740164 | 1.00 | DNM1 (0.75) | DNM1TSHRALDH1A1GPR84PPARG | |
| Bicarbonate SCHEMBL4389120 | 1.00 | DNM1 (0.75) | DNM1TSHRALDH1A1GPR84PPARG | |
| Bicarbonate SCHEMBL28531069 | 0.97 | DNM1 (0.70) | DNM1TSHRALDH1A1GPR84PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11866754-B2 | Trinucleotide mRNA cap analogs | MODERNATX, INC. (US) | 2024-01-09 | — | — | US | disclosed |
| EP-4086269-A1 | MRNA CAP ANALOGS WITH MODIFIED PHOSPHATE LINKAGE | ModernaTX, Inc. (US) | 2022-11-09 | — | — | EP | disclosed |
| EP-3362461-B1 | MRNA CAP ANALOGS WITH MODIFIED PHOSPHATE LINKAGE | MODERNATX INC (US) | 2022-03-16 | — | — | EP | disclosed |
| US-10570388-B2 | Phosphate replacement MRNA cap analogs | MODERNATX, INC. (US) | 2020-02-25 | — | — | US | disclosed |
| US-10563195-B2 | Phosphate replacement mRNA cap analogs | MODERNATX, INC. (US) | 2020-02-18 | — | — | US | disclosed |
| US-10428106-B2 | Phosphate replacement mRNA cap analogs | MODERNATX, INC. (US) | 2019-10-01 | — | — | US | disclosed |
| US-20190225644-A1 | MRNA CAP ANALOGS AND METHODS OF MRNA CAPPING | MODERNATX, INC. | 2019-07-25 | — | — | US | disclosed |
| US-20190218546-A1 | MRNA CAP ANALOGS WITH MODIFIED PHOSPHATE LINKAGE | MODERNATX, INC. | 2019-07-18 | — | — | US | disclosed |
| US-20190211368-A1 | TRINUCLEOTIDE MRNA CAP ANALOGS | MODERNATX, INC. | 2019-07-11 | — | — | US | disclosed |
| US-20180312535-A1 | PHOSPHATE REPLACEMENT MRNA CAP ANALOGS | ARES CAPITAL CORPORATION, AS AGENT | 2018-11-01 | — | — | US | disclosed |
| WO-2017066781-A1 | MRNA CAP ANALOGS WITH MODIFIED PHOSPHATE LINKAGE | MODERNATX, INC. (US) | 2017-04-20 | — | — | WO | disclosed |
| WO-2017066789-A1 | MRNA CAP ANALOGS WITH MODIFIED SUGAR | MODERNATX, INC. (US) | 2017-04-20 | — | — | WO | disclosed |
| WO-2017066797-A1 | TRINUCLEOTIDE MRNA CAP ANALOGS | MODERNATX, INC. (US) | 2017-04-20 | — | — | WO | disclosed |
| WO-2017066791-A1 | SUGAR SUBSTITUTED MRNA CAP ANALOGS | MODERNATX, INC. (US) | 2017-04-20 | — | — | WO | disclosed |
| EP-2596005-A2 | ANTIVIRAL AGENTS | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) | 2013-05-29 | — | — | EP | disclosed |
| US-20120010164-A1 | ANTIVIRAL AGENTS | SURNMA VINCENZO (IT) | 2012-01-12 | — | — | US | disclosed |
| US-20110306573-A1 | NUCLEOSIDE DERIVATIVES AS INHIBITORS OF VIRAL POLYMERASES | MERCK SHARP & DOHME CORP. | 2011-12-15 | — | — | US | disclosed |
| EP-2324043-A1 | NUCLEOSIDE DERIVATIVES AS INHIBITORS OF VIRAL POLYMERASES | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. (IT) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010084115-A2 | ANTIVIRAL AGENTS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2010-07-29 | — | — | WO | disclosed |
| WO-2010026153-A1 | NUCLEOSIDE DERIVATIVES AS INHIBITORS OF VIRAL POLYMERASES | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2010-03-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10428106-B2 | Phosphate replacement mRNA cap analogs | RNGTT, RNMT, CPSF6 | DNM1 3972/4885TSHR 2150/4885ALDH1A1 4428/4885 |
| US-20190211368-A1 | TRINUCLEOTIDE MRNA CAP ANALOGS | RNGTT, RNMT, CPSF7 | DNM1 2982/4885TSHR 2512/4885ALDH1A1 4506/4885 |
| US-10570388-B2 | Phosphate replacement MRNA cap analogs | RNGTT, RNMT, CPSF6 | DNM1 4037/4885TSHR 2112/4885ALDH1A1 4436/4885 |
| US-20180312535-A1 | PHOSPHATE REPLACEMENT MRNA CAP ANALOGS | RNGTT, RNMT, CPSF6 | DNM1 3972/4885TSHR 2150/4885ALDH1A1 4428/4885 |
| US-20190218546-A1 | MRNA CAP ANALOGS WITH MODIFIED PHOSPHATE LINKAGE | RNGTT, RNMT, CPSF7 | DNM1 2867/4885TSHR 3920/4885ALDH1A1 3970/4885 |
| US-20120010164-A1 | ANTIVIRAL AGENTS | EIF2AK2, HAVCR2, MAVS | DNM1 1402/4885TSHR 4227/4885ALDH1A1 738/4885 |
| US-11866754-B2 | Trinucleotide mRNA cap analogs | RNGTT, RNMT, CPSF7 | DNM1 2982/4885TSHR 2512/4885ALDH1A1 4506/4885 |
| US-10563195-B2 | Phosphate replacement mRNA cap analogs | RNGTT, RNMT, CPSF6 | DNM1 4037/4885TSHR 2112/4885ALDH1A1 4436/4885 |
| US-20190225644-A1 | MRNA CAP ANALOGS AND METHODS OF MRNA CAPPING | RNGTT, RNMT, NSUN2 | DNM1 2537/4885TSHR 3208/4885ALDH1A1 3967/4885 |
| US-20110306573-A1 | NUCLEOSIDE DERIVATIVES AS INHIBITORS OF VIRAL POLYMERASES | POLR2E, POLR2H, POLRMT | DNM1 1981/4885TSHR 4264/4885ALDH1A1 921/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.