Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.49 |
| ▸ | PLK1 | P53350 | 2/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 9/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.48 |
| ▸ | JAK3 | P52333 | 2/20 | 0.48 |
| ▸ | IGF1R | P08069 | 2/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | PAK4 | O96013 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30379611 | 1.00 | FGFR1 (0.49) | FGFR1FGFR2FGFR4FGFR3PLK1 | |
| SCHEMBL21596341 | 0.90 | EGFR (0.48) | FGFR1FGFR2FGFR4FGFR3PLK1 | |
| SCHEMBL28533769 | 0.88 | ALK (0.56) | FGFR1FGFR2FGFR4FGFR3PLK1 | |
| SCHEMBL30379391 | 0.87 | LRRK2 (0.49) | FGFR1FGFR2FGFR4FGFR3PLK1 | |
| SCHEMBL28909338 | 0.87 | ALK (0.55) | FGFR1FGFR2FGFR4FGFR3PLK1 | |
| SCHEMBL21596322 | 0.85 | LRRK2 (0.42) | FGFR1FGFR2FGFR4FGFR3PLK1 | |
| SCHEMBL21596323 | 0.85 | PDGFRA (0.53) | FGFR1FGFR2FGFR4FGFR3PLK1 | |
| SCHEMBL21596320 | 0.85 | ALK (0.41) | FGFR1FGFR2FGFR4FGFR3PLK1 | |
| SCHEMBL28953574 | 0.85 | ALK (0.53) | ALKIGF1RCDK2 | |
| SCHEMBL28953571 | 0.85 | ALK (0.58) | FGFR1FGFR2FGFR4FGFR3PLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313207-B | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2023-02-14 | — | — | CN | disclosed |
| CN-112313207-A | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2021-02-02 | — | — | CN | disclosed |