Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 20/20 | 0.58 |
| ▸ | INSR | P06213 | 15/20 | 0.58 |
| ▸ | IGF1R | P08069 | 15/20 | 0.58 |
| ▸ | AURKA | O14965 | 2/20 | 0.51 |
| ▸ | ROS1 | P08922 | 2/20 | 0.51 |
| ▸ | EML4 | Q9HC35 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 2/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | STK10 | O94804 | 1/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | SLC34A2 | O95436 | 1/20 | 0.49 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | CD74 | P04233 | 1/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | FES | P07332 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28533769 | 0.85 | ALK (0.56) | ALKIGF1RAURKAEGFRJAK2 | |
| SCHEMBL28532459 | 0.85 | FGFR1 (0.49) | ALKIGF1RAURKAEGFRJAK2 | |
| SCHEMBL30379611 | 0.85 | FGFR1 (0.49) | ALKIGF1RAURKAEGFRJAK2 | |
| SCHEMBL21600759 | 0.84 | IGF1R (0.51) | ALKINSRIGF1RAURKAEGFR | |
| SCHEMBL21596306 | 0.84 | ALK (0.51) | ALKINSRIGF1RAURKAROS1 | |
| SCHEMBL28909338 | 0.84 | ALK (0.55) | ALKIGF1RAURKAEGFRJAK2 | |
| SCHEMBL30380211 | 0.82 | PTK2 (0.51) | IGF1REGFRNUAK1PTK2 | |
| SCHEMBL28531524 | 0.82 | PTK2 (0.51) | IGF1REGFRNUAK1PTK2 | |
| SCHEMBL28604830 | 0.80 | SLC2A1 (0.59) | ALKINSRIGF1REGFRFGFR1 | |
| SCHEMBL28953574 | 0.80 | ALK (0.53) | ALKIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313207-B | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2023-02-14 | — | — | CN | disclosed |