Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 5/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.42 |
| ▸ | CTSC | P53634 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | BCR | P11274 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21596332 | 0.87 | FGFR1 (0.54) | MAPK10CTSCEGFRJAK3FGFR1 | |
| SCHEMBL28532003 | 0.84 | MAPK10 (0.51) | MAPK10CTSCCHEK1EGFRJAK3 | |
| SCHEMBL28535201 | 0.82 | MAPK10 (0.51) | MAPK10MAPK9CTSCCHEK1EGFR | |
| SCHEMBL28546158 | 0.75 | MAPK10 (0.42) | MAPK10CHEK1EGFRJAK3 | |
| SCHEMBL21600901 | 0.72 | FGFR1 (0.54) | CTSCEGFRJAK3FGFR1FGFR4 | |
| SCHEMBL30380211 | 0.71 | PTK2 (0.51) | EGFRPTK2IGF1RCDK2 | |
| SCHEMBL28531524 | 0.71 | PTK2 (0.51) | EGFRPTK2IGF1RCDK2 | |
| SCHEMBL30380064 | 0.71 | FGFR1 (0.55) | CTSCEGFRJAK3FGFR1FGFR4 | |
| SCHEMBL21600909 | 0.71 | FGFR1 (0.55) | MAPK10CTSCEGFRJAK3FGFR1 | |
| SCHEMBL21600988 | 0.71 | MAPK10 (0.46) | MAPK10CTSCCHEK1EGFRJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313207-B | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2023-02-14 | — | — | CN | disclosed |
| CN-112313207-A | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2021-02-02 | — | — | CN | disclosed |