Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 5/20 | 0.51 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.41 |
| ▸ | IGF1R | P08069 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 3/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28532003 | 0.86 | MAPK10 (0.51) | MAPK10CHEK1IGF1RCDK2JAK3 | |
| SCHEMBL21596351 | 0.85 | CSNK2A1 (0.44) | MAPK10CHEK1IGF1RCDK2CSNK2A1 | |
| SCHEMBL21600884 | 0.83 | MAPK10 (0.45) | MAPK10CHEK1IGF1RCSNK2A1JAK3 | |
| SCHEMBL28533109 | 0.82 | MAPK10 (0.48) | MAPK10CHEK1IGF1RCDK2JAK3 | |
| SCHEMBL21600886 | 0.82 | FGFR4 (0.53) | MAPK10JAK3EGFRFGFR1MAP2K1 | |
| SCHEMBL28546158 | 0.82 | MAPK10 (0.42) | MAPK10CHEK1JAK3EGFR | |
| SCHEMBL30380211 | 0.81 | PTK2 (0.51) | IGF1RCDK2EGFRPTK2 | |
| SCHEMBL28531524 | 0.81 | PTK2 (0.51) | IGF1RCDK2EGFRPTK2 | |
| SCHEMBL28533769 | 0.79 | ALK (0.56) | IGF1RJAK3EGFRMAPK9FGFR1 | |
| SCHEMBL28909338 | 0.79 | ALK (0.55) | IGF1RJAK3EGFRMAPK9FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313207-B | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2023-02-14 | — | — | CN | disclosed |
| CN-112313207-A | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2021-02-02 | — | — | CN | disclosed |