Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.73 |
| ▸ | MAPT | P10636 | 2/20 | 0.73 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.73 |
| ▸ | TSHR | P16473 | 2/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.73 |
| ▸ | BLM | P54132 | 1/20 | 0.73 |
| ▸ | AGER | Q15109 | 1/20 | 0.73 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ASPH | Q12797 | 2/20 | 0.43 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.43 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL28292423 | 0.93 | KDM4E (0.85) | KDM4EALDH1A1MAPTALOX15TSHR | |
| Quinolinic Acid SCHEMBL69230 | 0.86 | KDM4E (1.00) | KDM4EALDH1A1MAPTALOX15TSHR | |
| Quinolinic Acid SCHEMBL27676801 | 0.86 | KDM4E (1.00) | KDM4EALDH1A1MAPTALOX15TSHR | |
| Quinolinic Acid SCHEMBL29356188 | 0.86 | KDM4E (1.00) | KDM4EALDH1A1MAPTALOX15TSHR | |
| Quinolinic Acid SCHEMBL343618 | 0.86 | KDM4E (1.00) | KDM4EALDH1A1MAPTALOX15TSHR | |
| Quinolinic Acid SCHEMBL3744925 | 0.84 | KDM4E (0.96) | KDM4EALDH1A1MAPTALOX15TSHR | |
| Quinolinic Acid SCHEMBL5674125 | 0.84 | KDM4E (0.96) | KDM4EALDH1A1MAPTALOX15TSHR | |
| Quinolinic Acid SCHEMBL5361020 | 0.84 | KDM4E (0.96) | KDM4EALDH1A1MAPTALOX15TSHR | |
| Quinolinic Acid SCHEMBL1897909 | 0.84 | KDM4E (0.96) | KDM4EALDH1A1MAPTALOX15TSHR | |
| Quinolinic Acid SCHEMBL21326209 | 0.84 | KDM4E (0.96) | KDM4EALDH1A1MAPTALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109648976-B | Co-extrusion two-way stretching PET/PPS composite film and preparation method thereof | 四川东方绝缘材料股份有限公司 | 2021-03-16 | — | — | CN | disclosed |