Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.85 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.85 |
| ▸ | MAPT | P10636 | 2/20 | 0.85 |
| ▸ | TSHR | P16473 | 2/20 | 0.85 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.85 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.85 |
| ▸ | BLM | P54132 | 1/20 | 0.85 |
| ▸ | AGER | Q15109 | 1/20 | 0.85 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.85 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.85 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | ASPH | Q12797 | 1/20 | 0.47 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL28533196 | 0.93 | KDM4E (0.73) | KDM4EALDH1A1MAPTTSHRALOX15 | |
| Quinolinic Acid SCHEMBL69230 | 0.92 | KDM4E (1.00) | KDM4EALDH1A1MAPTTSHRALOX15 | |
| Quinolinic Acid SCHEMBL27676801 | 0.92 | KDM4E (1.00) | KDM4EALDH1A1MAPTTSHRALOX15 | |
| Quinolinic Acid SCHEMBL29356188 | 0.92 | KDM4E (1.00) | KDM4EALDH1A1MAPTTSHRALOX15 | |
| Quinolinic Acid SCHEMBL343618 | 0.92 | KDM4E (1.00) | KDM4EALDH1A1MAPTTSHRALOX15 | |
| Quinolinic Acid SCHEMBL5381551 | 0.90 | KDM4E (0.96) | KDM4EALDH1A1MAPTTSHRALOX15 | |
| Quinolinic Acid SCHEMBL890367 | 0.90 | KDM4E (0.96) | KDM4EALDH1A1MAPTTSHRALOX15 | |
| Quinolinic Acid SCHEMBL3744925 | 0.90 | KDM4E (0.96) | KDM4EALDH1A1MAPTTSHRALOX15 | |
| Quinolinic Acid SCHEMBL21326209 | 0.90 | KDM4E (0.96) | KDM4EALDH1A1MAPTTSHRALOX15 | |
| Quinolinic Acid SCHEMBL5361020 | 0.90 | KDM4E (0.96) | KDM4EALDH1A1MAPTTSHRALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109648976-A | A kind of co-extruding biaxial stretched PET/PPS laminated film and preparation method thereof | 四川东方绝缘材料股份有限公司 | 2019-04-19 | — | — | CN | claimed |
| CN-109648976-A | A kind of co-extruding biaxial stretched PET/PPS laminated film and preparation method thereof | 四川东方绝缘材料股份有限公司 | 2019-04-19 | — | — | CN | disclosed |