Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 2/20 | 0.33 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28529440 | 1.00 | GRIK1 (0.33) | GRIK1GRIK2MAPTMAPK1LMNA | |
| SCHEMBL28529438 | 1.00 | GRIK1 (0.33) | GRIK1GRIK2MAPTMAPK1LMNA | |
| SCHEMBL29102854 | 0.82 | GRIK1 (0.32) | GRIK1GRIK2LMNACHRM2CHRM4 | |
| SCHEMBL28530618 | 0.81 | GRIK1 (0.30) | GRIK1GRIK2 | |
| SCHEMBL2480097 | 0.79 | — | — | |
| SCHEMBL29131720 | 0.79 | MAPT (0.32) | MAPTMAPK1 | |
| SCHEMBL29131719 | 0.79 | MAPT (0.32) | MAPTMAPK1 | |
| SCHEMBL6834592 | 0.77 | CA1 (0.39) | MAPT | |
| SCHEMBL28529532 | 0.76 | GRIK1 (0.37) | GRIK1GRIK2MAPTMAPK1LMNA | |
| SCHEMBL1872666 | 0.76 | LMNA (0.34) | GRIK1GRIK2MAPTLMNACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112351778-B | Fused tricyclic heterocycles and therapeutic uses thereof | 江苏恒瑞医药股份有限公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-112351778-A | Fused tricyclic heterocycles and therapeutic uses thereof | 江苏恒瑞医药股份有限公司 | 2021-02-09 | — | — | CN | disclosed |