SCHEMBL28533366

SCHEMBL28533366

O=C1C(=O)N(CCCCCCCCCCN2C(=O)C(=O)c3cc(Cl)ccc32)c2ccc(Cl)cc21

nearest known ligand 0.74

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
ALDH3A1 P30838 7/20 0.67
ALDH1A1 P00352 4/20 0.67
ALDH2 P05091 4/20 0.67
CES1 P23141 2/20 0.53
CDC25A P30304 1/20 0.53
CHRM5 P08912 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3025055 0.93 CES1 (0.65) ALDH3A1ALDH1A1ALDH2CES1CDC25A
SCHEMBL29011261 0.93 ALDH3A1 (0.59) ALDH3A1ALDH1A1ALDH2CES1CDC25A
SCHEMBL16366714 0.91 ALDH1A1 (0.64) ALDH3A1ALDH1A1ALDH2CES1CDC25A
SCHEMBL29011259 0.91 ALDH3A1 (0.60) ALDH3A1ALDH1A1ALDH2CES1CHRM5
SCHEMBL11150299 0.90 ALDH1A1 (0.63) ALDH3A1ALDH1A1ALDH2CHRM5
SCHEMBL29011260 0.89 ALDH3A1 (0.62) ALDH3A1ALDH1A1ALDH2CES1CHRM5
SCHEMBL16046979 0.89 ALDH1A1 (0.62) ALDH3A1ALDH1A1ALDH2CES1CDC25A
SCHEMBL17286209 0.85 ALDH3A1 (0.65) ALDH3A1ALDH1A1ALDH2CES1CHRM5
SCHEMBL16048101 0.85 ALDH3A1 (0.65) ALDH3A1ALDH1A1ALDH2CHRM5
SCHEMBL29220078 0.85 ALDH3A1 (0.65) ALDH3A1ALDH1A1ALDH2CES1CHRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112538041-A Bimolecular indole-2, 3-dione derivative and application thereof 浙江大学 2021-03-23 CN claimed