Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.46 |
| ▸ | APP | P05067 | 2/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18832001 | 0.81 | PTK2 (0.62) | PTK2 | |
| SCHEMBL25637824 | 0.80 | PTK2 (0.54) | PTK2CDK7CDK9INSRIGF1R | |
| SCHEMBL9776701 | 0.79 | SLC2A1 (0.59) | PDE5AAPPSMN1; SMN2LMNA | |
| SCHEMBL9776796 | 0.78 | MEN1 (0.60) | PDE5AAPPMAPTKMT2AKDM4E | |
| SCHEMBL13380482 | 0.77 | ULK1 (0.54) | PDE5AAPPPTK2CDK7CDK9 | |
| Hydrochloric Acid SCHEMBL9776744 | 0.77 | SLC2A1 (0.62) | PDE5AAPPSMN1; SMN2LMNA | |
| SCHEMBL29400320 | 0.77 | CDK7 (0.60) | PTK2CDK7CDK9INSRIGF1R | |
| SCHEMBL11916362 | 0.77 | CDK7 (0.60) | PTK2CDK7CDK9INSRIGF1R | |
| SCHEMBL14240767 | 0.76 | CDK7 (0.48) | PTK2CDK7CDK9INSRIGF1R | |
| SCHEMBL30503695 | 0.76 | CDK7 (0.48) | PTK2CDK7CDK9INSRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112538072-B | Aminopyrimidine EGFR inhibitors | 齐鲁制药有限公司 | 2024-02-06 | — | — | CN | disclosed |
| CN-112538072-A | Novel aminopyrimidine EGFR (epidermal growth factor receptor) inhibitor | 齐鲁制药有限公司 | 2021-03-23 | — | — | CN | disclosed |