Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.36 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.34 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.34 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15104669 | 0.77 | RAB9A (0.46) | EGFRERBB2RAB9AKDM4EALDH1A1 | |
| SCHEMBL2772081 | 0.76 | RAB9A (0.50) | EGFRERBB2RAB9AKDM4EALDH1A1 | |
| SCHEMBL10707072 | 0.70 | EGLN2 (0.51) | RAB9AKDM4EALDH1A1MAPTL3MBTL1 | |
| SCHEMBL17967008 | 0.70 | GSK3B (0.51) | EGFRERBB2RAB9AALDH1A1MAPK1 | |
| SCHEMBL6902503 | 0.70 | MAPT (0.42) | EGFRERBB2RAB9AKDM4EALDH1A1 | |
| SCHEMBL7158819 | 0.70 | L3MBTL1 (0.64) | EGFRERBB2RAB9AKDM4EALDH1A1 | |
| SCHEMBL374899 | 0.70 | KMT2A (0.46) | EGFRERBB2RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL3226652 | 0.69 | EGFR (0.43) | EGFRERBB2RAB9AKDM4EALDH1A1 | |
| SCHEMBL27742417 | 0.69 | GAA (0.45) | EGFRERBB2RAB9AKDM4EALDH1A1 | |
| SCHEMBL1691036 | 0.68 | MAPT (0.51) | EGFRERBB2RAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112979660-A | Bicyclic lactams and methods of use thereof | 豪夫迈·罗氏有限公司 | 2021-06-18 | — | — | CN | disclosed |
| CN-107849023-B | Bicyclic lactams and methods of use thereof | 豪夫迈·罗氏有限公司 | 2021-03-23 | — | — | CN | disclosed |