Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 16/20 | 0.58 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | WEE1 | P30291 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28527347 | 0.95 | CSF1R (0.57) | CSF1R | |
| SCHEMBL28528317 | 0.92 | CSF1R (0.54) | CSF1RAURKAAURKBWEE1INSR | |
| SCHEMBL28527136 | 0.89 | CSF1R (0.56) | CSF1RKDM5B | |
| SCHEMBL28522950 | 0.85 | CSF1R (0.53) | CSF1R | |
| SCHEMBL28536120 | 0.84 | CSF1R (0.55) | CSF1RINSRPDGFRBKITSRC | |
| SCHEMBL3290842 | 0.84 | CSF1R (0.62) | CSF1RMAPK8KDM5B | |
| SCHEMBL3524940 | 0.83 | CSF1R (0.77) | CSF1RINSRPDGFRBKITSRC | |
| SCHEMBL28529959 | 0.83 | CSF1R (0.56) | CSF1RINSRPDGFRBKITSRC | |
| SCHEMBL3290621 | 0.82 | CSF1R (0.75) | CSF1RMAPK8KITSRCFLT3 | |
| SCHEMBL3290854 | 0.81 | CSF1R (0.56) | CSF1RSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111848613-A | Diaryl pyrimidopyridinone derivative and preparation method and application thereof | 山东大学 | 2020-10-30 | — | — | CN | claimed |
| CN-111848613-B | Diaryl pyrimidopyridinone derivative and preparation method and application thereof | 山东大学 | 2021-09-24 | — | — | CN | disclosed |
| CN-111848613-A | Diaryl pyrimidopyridinone derivative and preparation method and application thereof | 山东大学 | 2020-10-30 | — | — | CN | disclosed |