Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL284938 | 0.89 | HDAC8 (0.56) | HDAC8HDAC6HDAC1HDAC2HDAC3 | |
| SCHEMBL284853 | 0.88 | HDAC3 (0.56) | HDAC8HDAC6HDAC1HDAC2HDAC3 | |
| SCHEMBL284894 | 0.86 | HDAC6 (0.57) | HDAC8HDAC6HDAC1HDAC2HDAC3 | |
| SCHEMBL18350826 | 0.82 | MEN1 (0.51) | HDAC8HDAC6HDAC1HDAC2HDAC3 | |
| SCHEMBL18350824 | 0.76 | MEN1 (0.62) | HDAC8HDAC6HDAC1HDAC2HDAC3 | |
| SCHEMBL17732161 | 0.76 | PTGS1 (0.73) | LMNATSHRALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL1110826 | 0.76 | HTR2A (0.58) | HDAC8HDAC6HDAC1HDAC2HDAC3 | |
| SCHEMBL29725098 | 0.76 | HTR2A (0.58) | HDAC8HDAC6HDAC1HDAC2HDAC3 | |
| SCHEMBL8025555 | 0.75 | HTR2A (0.60) | HDAC8HDAC6HDAC1HDAC2LMNA | |
| SCHEMBL1368072 | 0.75 | HDAC6 (0.69) | HDAC8HDAC6HDAC1HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9580749-B2 | Dyes and labeled molecules | BIOTIUM, INC. (US) | 2017-02-28 | — | — | US | disclosed |
| US-9102835-B2 | Methods of using dyes in association with nucleic acid staining or detection and associated technology | BIOTIUM, INC. (US) | 2015-08-11 | — | — | US | disclosed |
| US-8753814-B2 | Methods of using dyes in association with nucleic acid staining or detection and associated technology | BIOTIUM, INC. (US) | 2014-06-17 | — | — | US | disclosed |
| US-20140106349-A1 | Dyes and Labeled Molecules | ALLELOGIC BIOSCIENCES CORPORATION (US) | 2014-04-17 | — | — | US | disclosed |
| US-20140073058-A1 | Methods of Using Dyes in Association with Nucleic Acid Staining or Detection and Associated Technology | BIOTIUM, INC. (US) | 2014-03-13 | — | — | US | disclosed |
| US-8530195-B2 | Dyes and labeled molecules | BIOTIUM, INC. (US) | 2013-09-10 | — | — | US | disclosed |
| US-20130167309-A1 | METHODS OF USING DYES IN ASSOCIATION WITH NUCLEIC ACID STAINING OR DETECTION AND ASSOCIATED TECHNOLOGY | BIOTIUM, INC. (US) | 2013-07-04 | — | — | US | disclosed |
| EP-2428586-B1 | Dimeric nucleic acid dyes, and associated systems and methods | BIOTIUM INC (US) | 2013-05-08 | — | — | EP | disclosed |
| US-8232050-B2 | Methods of using dyes in association with nucleic acid staining or detection and associated technology | BIOTIUM, INC. (US) | 2012-07-31 | — | — | US | disclosed |
| EP-2428586-A1 | Dimeric and trimeric nucleic acid dyes, and associated systems and methods | Biotium Inc. (US) | 2012-03-14 | — | — | EP | disclosed |
| US-20100317016-A1 | DYES AND LABELED MOLECULES | BIOTIUM, INC. (US) | 2010-12-16 | — | — | US | disclosed |
| US-7803943-B2 | Methods of using dyes in association with nucleic acid staining or detection and associated technology | BIOTIUM, INC. (US) | 2010-09-28 | — | — | US | disclosed |
| US-7776567-B2 | Dimeric and trimeric nucleic acid dyes, and associated systems and methods | BIOTIUM, INC. (US) | 2010-08-17 | — | — | US | disclosed |
| US-20100009454-A1 | METHODS OF USING DYES IN ASSOCIATION WITH NUCLEIC ACID STAINING OR DETECTION AND ASSOCIATED TECHNOLOGY | BIOTIUM, INC. | 2010-01-14 | — | — | US | disclosed |
| US-7601498-B2 | Methods of using dyes in association with nucleic acid staining or detection and associated technology | BIOTIUM, INC. (US) | 2009-10-13 | — | — | US | disclosed |
| EP-1863933-A4 | DIMERIC AND TRIMERIC NUCLEIC ACID DYES, AND ASSOCIATED SYSTEMS AND METHODS | BIOTIUM INC (US) | 2009-04-08 | — | — | EP | disclosed |
| EP-1863933-A2 | DIMERIC AND TRIMERIC NUCLEIC ACID DYES, AND ASSOCIATED SYSTEMS AND METHODS | Biotium Inc. (US) | 2007-12-12 | — | — | EP | disclosed |
| US-20060211028-A1 | Dimeric and trimeric nucleic acid dyes, and associated systems and methods | ALLELOGIC BIOSCIENCES CORPORATION | 2006-09-21 | — | — | US | disclosed |
| US-20060211029-A1 | Methods of using dyes in association with nucleic acid staining or detection and associated technology | BIOTIUM, INC. | 2006-09-21 | — | — | US | disclosed |
| WO-2006099605-A2 | DIMERIC AND TRIMERIC NUCLEIC ACID DYES, AND ASSOCIATED SYSTEMS AND METHODS | BIOTIUM, INC. (US) | 2006-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100317016-A1 | DYES AND LABELED MOLECULES | DNA2, POLL, POLRMT | HDAC8 4235/4885HDAC6 4703/4885HDAC1 4195/4885 |
| US-20060211028-A1 | Dimeric and trimeric nucleic acid dyes, and associated systems and methods | DNA2, POLRMT, POLL | HDAC8 3985/4885HDAC6 4479/4885HDAC1 4182/4885 |
| US-20060211029-A1 | Methods of using dyes in association with nucleic acid staining or detection and associated technology | HNRNPLL, HNRNPL, HNRNPH3 | HDAC8 2605/4885HDAC6 3525/4885HDAC1 2611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.