Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 4/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2848057 | 0.88 | MARS1 (0.44) | CNR2CNR1LMNA | |
| SCHEMBL2848002 | 0.88 | CNR2 (0.53) | CNR2CNR1 | |
| SCHEMBL13411493 | 0.82 | CNR2 (0.47) | CNR2CNR1 | |
| SCHEMBL14625769 | 0.81 | CNR1 (0.53) | CNR2CNR1 | |
| SCHEMBL14450139 | 0.79 | CNR1 (0.60) | CNR2CNR1 | |
| SCHEMBL3470457 | 0.76 | MARS1 (0.45) | CNR2CNR1 | |
| SCHEMBL14089383 | 0.76 | CNR2 (0.43) | CNR2CNR1 | |
| SCHEMBL176432 | 0.76 | CNR2 (0.57) | CNR2CNR1 | |
| SCHEMBL2849871 | 0.76 | CNR1 (0.52) | CNR2CNR1 | |
| SCHEMBL13411468 | 0.76 | CNR1 (0.52) | CNR2CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100069341-A1 | TETRAHYDRO-PYRANOPYRAZOLE CANNABINOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-03-18 | — | — | US | claimed |
| US-20070155723-A1 | Tetrahydro-pyranopyrazole cannabinoid modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-05 | — | — | US | claimed |
| US-20100069341-A1 | TETRAHYDRO-PYRANOPYRAZOLE CANNABINOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-03-18 | — | — | US | disclosed |
| US-20100069341-A1 | TETRAHYDRO-PYRANOPYRAZOLE CANNABINOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-03-18 | — | — | US | disclosed |
| US-20100069341-A1 | TETRAHYDRO-PYRANOPYRAZOLE CANNABINOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-03-18 | — | — | US | disclosed |
| US-20070155723-A1 | Tetrahydro-pyranopyrazole cannabinoid modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-05 | — | — | US | disclosed |
| US-20070155723-A1 | Tetrahydro-pyranopyrazole cannabinoid modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-05 | — | — | US | disclosed |
| US-20070155723-A1 | Tetrahydro-pyranopyrazole cannabinoid modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070155723-A1 | Tetrahydro-pyranopyrazole cannabinoid modulators | CNR2, CNR1, GPR18 | CNR2 1/4885SIGMAR1 562/4885TMEM97 531/4885 |
| US-20100069341-A1 | TETRAHYDRO-PYRANOPYRAZOLE CANNABINOID MODULATORS | CNR2, CNR1, GPR18 | CNR2 1/4885SIGMAR1 562/4885TMEM97 531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.