Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.67 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.59 |
| ▸ | CDK1 | P06493 | 1/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | CDK7 | P50613 | 1/20 | 0.56 |
| ▸ | CCNH | P51946 | 1/20 | 0.56 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.56 |
| ▸ | PLK1 | P53350 | 6/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.52 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.52 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.52 |
| ▸ | IGF1R | P08069 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.44 |
| ▸ | ROS1 | P08922 | 1/20 | 0.44 |
| ▸ | EML4 | Q9HC35 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28542726 | 0.88 | FLT3 (0.59) | EGFRALKCDK1CCNB1FLT3 | |
| SCHEMBL21600982 | 0.85 | EGFR (0.58) | EGFRALKCDK1CCNB1FLT3 | |
| SCHEMBL28537409 | 0.85 | EGFR (0.58) | EGFRALKCDK1CCNB1FLT3 | |
| SCHEMBL517613 | 0.81 | EGFR (0.75) | EGFRALKPLK1IGF1RCDK2 | |
| SCHEMBL518394 | 0.80 | ALK (0.83) | EGFRALKIGF1RAURKAINSR | |
| SCHEMBL517036 | 0.80 | EGFR (0.74) | EGFRALKPLK1IGF1RCDK2 | |
| SCHEMBL517565 | 0.80 | EGFR (0.81) | EGFRALKCDK1CCNB1FLT3 | |
| SCHEMBL28537291 | 0.79 | PLK1 (0.63) | EGFRALKPLK1FGFR1FGFR2 | |
| SCHEMBL517301 | 0.79 | EGFR (0.72) | EGFRALKCDK7CCNHMNAT1 | |
| SCHEMBL21600992 | 0.77 | EGFR (0.53) | EGFRCDK1CCNB1FLT3CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112313207-B | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2023-02-14 | — | — | CN | disclosed |
| CN-112313207-A | Cyano-substituted pyridine and cyano-substituted pyrimidine compounds, and preparation methods and applications thereof | 北京赛特明强医药科技有限公司 | 2021-02-02 | — | — | CN | disclosed |