Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 15/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL109295 | 0.95 | GCGR (0.35) | GCGRTLR8TLR7 | |
| SCHEMBL8995000 | 0.89 | TLR8 (0.38) | GCGRTLR8TLR7 | |
| SCHEMBL15255830 | 0.79 | TLR8 (0.34) | TLR8TLR7 | |
| SCHEMBL13059078 | 0.79 | NPSR1 (0.37) | GCGR | |
| SCHEMBL285798 | 0.76 | LMNA (0.33) | TLR8TLR7 | |
| SCHEMBL285480 | 0.76 | TLR8 (0.36) | TLR8TLR7 | |
| SCHEMBL5734668 | 0.76 | PPARA (0.33) | GCGRTLR8TLR7 | |
| SCHEMBL18647926 | 0.75 | TLR8 (0.42) | TLR8TLR7 | |
| SCHEMBL17514350 | 0.74 | MLYCD (0.40) | TLR8TLR7 | |
| SCHEMBL18898429 | 0.73 | TLR8 (0.41) | TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427457-A1 | ISOXAZOLE-PYRIDINE DERIVATIVES AS GABA MODULATORS | F. Hoffmann-La Roche AG (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010127978-A1 | ISOXAZOLE-PYRIDINE DERIVATIVES AS GABA MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-11-11 | — | — | WO | disclosed |