Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 13/20 | 0.41 |
| ▸ | JAK2 | O60674 | 12/20 | 0.38 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18588959 | 1.00 | NTRK1 (0.41) | NTRK1JAK2ABHD6TACR1 | |
| SCHEMBL451781 | 0.83 | RIPK1 (0.50) | NTRK1JAK2TACR1 | |
| SCHEMBL430829 | 0.83 | RIPK1 (0.50) | NTRK1JAK2TACR1 | |
| SCHEMBL21723215 | 0.83 | RIPK1 (0.50) | NTRK1JAK2TACR1 | |
| SCHEMBL29744544 | 0.83 | RIPK1 (0.50) | NTRK1JAK2TACR1 | |
| SCHEMBL18555578 | 0.82 | NTRK1 (0.43) | NTRK1JAK2ABHD6 | |
| SCHEMBL18555577 | 0.82 | NTRK1 (0.43) | NTRK1JAK2ABHD6 | |
| SCHEMBL24526756 | 0.81 | TACR1 (0.35) | NTRK1JAK2TACR1 | |
| SCHEMBL29759291 | 0.81 | TACR1 (0.35) | NTRK1JAK2TACR1 | |
| SCHEMBL18878228 | 0.80 | RIPK1 (0.49) | NTRK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108137607-B | Compounds and compositions suitable for treating NTRK-related disorders | 缆图药品公司 | 2021-04-06 | — | — | CN | disclosed |