SCHEMBL28538744

SCHEMBL28538744

C=C(CCC)[Si](C)(C)c1ccccc1

nearest known ligand 0.37

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CES2 O00748 2/20 0.37
CES1 P23141 2/20 0.37
ESR1 P03372 2/20 0.36
ESR2 Q92731 1/20 0.36
HPGD P15428 3/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
ALOX5 P09917 1/20 0.34
TP53 P04637 1/20 0.34
MAPT P10636 4/20 0.33
ALDH1A1 P00352 4/20 0.33
KDM4E B2RXH2 2/20 0.33
GAA P10253 2/20 0.33
GLA P06280 1/20 0.33
RAB9A P51151 1/20 0.33
PTGS2 P35354 1/20 0.32
ADORA1 P30542 1/20 0.32
CYP2C19 P33261 1/20 0.32
RECQL P46063 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7900984 0.72 ESR1 (0.43) CES2CES1ESR1ESR2HPGD
SCHEMBL5779320 0.70 ESR1 (0.41) CES2CES1ESR1ESR2HPGD
SCHEMBL552036 0.67 ESR1 (0.39) ESR1ESR2HPGDMAPTALDH1A1
SCHEMBL78217 0.66 CES2 (0.52) CES2CES1ESR1HPGDSMN1; SMN2
SCHEMBL9227536 0.65 ESR1 (0.38) ESR1ESR2SMN1; SMN2L3MBTL1MAPT
SCHEMBL25179725 0.64 MAPT (0.33) ESR1ESR2MAPTALDH1A1KDM4E
SCHEMBL6874393 0.64 ESR1 (0.50) CES2CES1ESR1ESR2HPGD
Alcohol SCHEMBL28285118 0.64 ESR1 (0.44) CES2CES1ESR1ESR2L3MBTL1
SCHEMBL16706156 0.64 ESR1 (0.44) CES2CES1ESR1ESR2HPGD
SCHEMBL27085641 0.64 TSHR (0.37) CES2CES1ESR1ESR2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112409118-A Method for electrochemically synthesizing trans-4- (trans-4' -alkylcyclohexyl) cyclohexyl vinyl liquid crystal monomer 惠泽化学科技(濮阳)有限公司 2021-02-26 CN disclosed