Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 18/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.41 |
| ▸ | KDR | P35968 | 6/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.38 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28552520 | 0.93 | TGFBR1 (0.42) | TGFBR1MAPK14KDRPPARDPPARA | |
| SCHEMBL29528228 | 0.83 | TGFBR1 (0.41) | TGFBR1MAPK14KDRRIPK2ACVR1B | |
| SCHEMBL21932018 | 0.83 | TGFBR1 (0.41) | TGFBR1MAPK14KDRRIPK2ACVR1B | |
| SCHEMBL5907484 | 0.82 | TGFBR1 (0.50) | TGFBR1MAPK14KDRRIPK2 | |
| SCHEMBL31373673 | 0.81 | TGFBR1 (0.40) | TGFBR1MAPK14KDRRIPK2ACVR1B | |
| SCHEMBL23873805 | 0.81 | TGFBR1 (0.42) | TGFBR1MAPK14KDRPPARDPPARA | |
| SCHEMBL21932064 | 0.80 | TGFBR1 (0.46) | TGFBR1MAPK14KDRRIPK2 | |
| SCHEMBL21375765 | 0.79 | TGFBR1 (0.44) | TGFBR1MAPK14KDRRIPK2 | |
| SCHEMBL5907474 | 0.79 | TGFBR1 (0.46) | TGFBR1MAPK14KDRRIPK2 | |
| SCHEMBL5907522 | 0.78 | MAT2A (0.43) | TGFBR1MAPK14KDRRIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115052663-A | ALK5 inhibitor conjugates and uses thereof | 辛瑟斯治疗股份有限公司 | 2022-09-13 | — | — | CN | disclosed |
| CN-114269388-A | antibody-ALK 5 inhibitor conjugates and uses thereof | 辛瑟斯治疗股份有限公司 | 2022-04-01 | — | — | CN | disclosed |
| CN-112601522-A | antibody-ALK 5 inhibitor conjugates and uses thereof | 辛瑟斯治疗股份有限公司 | 2021-04-02 | — | — | CN | disclosed |