Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.39 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.39 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.39 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.39 |
| ▸ | STIM2 | Q9P246 | 1/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | GPR6 | P46095 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 3/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2856094 | 0.94 | MAPT (0.42) | MAPTNPSR1NPC1RAB9ATRPC3 | |
| SCHEMBL2855318 | 0.84 | ROCK1 (0.43) | MAPTNPSR1NPC1RAB9ATRPC3 | |
| SCHEMBL2852086 | 0.79 | ITGB3 (0.53) | MAPTNPSR1NPC1RAB9ATRPC3 | |
| SCHEMBL2854478 | 0.79 | ITGB3 (0.46) | MAPTNPSR1NPC1RAB9ATRPC3 | |
| SCHEMBL2858063 | 0.79 | MAPT (0.57) | MAPTNPSR1NPC1RAB9ATRPC3 | |
| SCHEMBL2858117 | 0.77 | MAPT (0.41) | MAPTNPSR1NPC1RAB9AGPR6 | |
| SCHEMBL2854455 | 0.77 | KMT2A (0.50) | MAPTNPSR1GAAALDH1A1CCR1 | |
| SCHEMBL10366449 | 0.76 | MAPT (0.53) | MAPTNPSR1NPC1RAB9ATRPC3 | |
| SCHEMBL2859797 | 0.76 | MAPT (0.49) | MAPTNPSR1NPC1RAB9ATRPC3 | |
| SCHEMBL2860983 | 0.75 | MAPT (0.49) | MAPTNPSR1NPC1RAB9ATRPC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |