Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.46 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.46 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.46 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.46 |
| ▸ | STIM2 | Q9P246 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CCR1 | P32246 | 3/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2850038 | 0.86 | MAPT (0.46) | MAPTTRPC3TRPC1STIM1ORAI1 | |
| SCHEMBL2858063 | 0.81 | MAPT (0.57) | MAPTTRPC3TRPC1STIM1ORAI1 | |
| SCHEMBL2860983 | 0.80 | MAPT (0.49) | MAPTTRPC3TRPC1STIM1ORAI1 | |
| SCHEMBL2859050 | 0.80 | PTGS1 (0.46) | MAPTNPC1RAB9ANPSR1SMN1; SMN2 | |
| SCHEMBL2859651 | 0.79 | MAPT (0.46) | MAPTTRPC3TRPC1STIM1ORAI1 | |
| SCHEMBL2856049 | 0.78 | ATM (0.53) | MAPTNPC1RAB9ANPSR1SMN1; SMN2 | |
| SCHEMBL2854032 | 0.76 | MAPT (0.43) | MAPTTRPC3TRPC1STIM1ORAI1 | |
| SCHEMBL2859981 | 0.75 | KDM4E (0.50) | MAPTORAI1NPC1RAB9ANPSR1 | |
| SCHEMBL2854478 | 0.75 | ITGB3 (0.46) | MAPTTRPC3TRPC1STIM1ORAI1 | |
| SCHEMBL2856795 | 0.75 | NPC1 (0.46) | MAPTTRPC3TRPC1STIM1ORAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |