SCHEMBL28541027

SCHEMBL28541027

Clc1cc(Cl)nc(-c2cc3ccccc3c3ccccc23)n1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 1/20 0.44
ALDH1A1 P00352 3/20 0.42
HSD17B10 Q99714 3/20 0.42
L3MBTL1 Q9Y468 3/20 0.42
HIF1A Q16665 2/20 0.42
MAPK1 P28482 2/20 0.42
TSHR P16473 2/20 0.42
HPGD P15428 1/20 0.42
CASP1 P29466 1/20 0.42
NISCH Q9Y2I1 1/20 0.42
KMT2A Q03164 1/20 0.42
TRPM4 Q8TD43 1/20 0.42
CYP1B1 Q16678 1/20 0.41
HPRT1 P00492 1/20 0.39
LMNA P02545 2/20 0.39
MAPT P10636 2/20 0.39
CYP3A4 P08684 1/20 0.39
APEX1 P27695 1/20 0.39
PMP22 Q01453 1/20 0.39
PAX8 Q06710 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17412430 0.91 HSP90AA1 (0.41) CYP11B1ALDH1A1HSD17B10L3MBTL1HIF1A
SCHEMBL17412390 0.86 KDM4E (0.51) CYP11B1ALDH1A1HSD17B10L3MBTL1MAPK1
SCHEMBL13314087 0.85 CYP11B1 (0.52) CYP11B1ALDH1A1HSD17B10L3MBTL1HIF1A
SCHEMBL30305692 0.84 CYP11B1 (0.44) CYP11B1ALDH1A1HSD17B10L3MBTL1HIF1A
SCHEMBL29751137 0.84 POLB (0.46) CYP11B1ALDH1A1HSD17B10L3MBTL1HIF1A
SCHEMBL24030117 0.84 POLB (0.46) CYP11B1ALDH1A1HSD17B10L3MBTL1HIF1A
SCHEMBL17084859 0.84 CYP11B1 (0.44) CYP11B1ALDH1A1HSD17B10L3MBTL1HIF1A
SCHEMBL10498207 0.80 KMT2A (0.46) ALDH1A1HSD17B10L3MBTL1HIF1AMAPK1
SCHEMBL17412410 0.79 LMNA (0.51) CYP11B1ALDH1A1L3MBTL1MAPK1HPGD
SCHEMBL22274007 0.79 KDM4E (0.47) CYP11B1ALDH1A1HSD17B10L3MBTL1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112538056-A Electron transport material and organic electroluminescent device containing same 南京高光半导体材料有限公司 2021-03-23 CN disclosed