Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 4/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19127405 | 0.85 | KDM4E (0.39) | MAPTSMN1; SMN2POLBKDM4EALDH1A1 | |
| SCHEMBL19128175 | 0.82 | KDM4E (0.45) | MAPTSMN1; SMN2POLBKDM4EKDM4C | |
| SCHEMBL19128038 | 0.81 | EPHX2 (0.35) | MAPTSMN1; SMN2POLBKDM4EKDM4C | |
| SCHEMBL19128573 | 0.78 | CNR2 (0.39) | KDM4EMEN1LMNAKMT2A | |
| SCHEMBL19127961 | 0.73 | SMN1; SMN2 (0.36) | MAPTSMN1; SMN2POLBKDM4EKDM4C | |
| SCHEMBL30322820 | 0.73 | NR4A3 (0.40) | MAPTSMN1; SMN2POLBKDM4EKDM4C | |
| SCHEMBL24247736 | 0.72 | KDM4E (0.39) | MAPTSMN1; SMN2POLBKDM4EALDH1A1 | |
| SCHEMBL20646954 | 0.72 | LMNA (0.38) | MAPTSMN1; SMN2KDM4ETDP1ALDH1A1 | |
| SCHEMBL23889040 | 0.70 | SLC6A9 (0.35) | SMN1; SMN2KDM4ETDP1ALDH1A1LMNA | |
| SCHEMBL28553049 | 0.70 | KDM4E (0.39) | MAPTSMN1; SMN2KDM4EKDM4CTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108699038-B | Spirocyclic heptane salicylamides and related compounds as Rock inhibitors | 百时美施贵宝公司 | 2021-04-16 | — | — | CN | disclosed |