Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.52 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.52 |
| ▸ | GPR6 | P46095 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.46 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.45 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.44 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.44 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.44 |
| ▸ | STIM2 | Q9P246 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10366507 | 0.88 | MAPT (0.50) | MAPTPOLBSMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL10365006 | 0.86 | MAPT (0.72) | MAPTPOLBSMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL10366449 | 0.86 | MAPT (0.53) | MAPTPOLBSMN1; SMN2GPR6ACHE | |
| SCHEMBL13513682 | 0.85 | MAPT (0.57) | MAPTPOLBSMN1; SMN2GPR6ACHE | |
| SCHEMBL10365412 | 0.85 | MAPT (0.51) | MAPTPOLBSMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL2923068 | 0.84 | HSD11B1 (0.51) | MAPTPOLBSMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL2856010 | 0.83 | MAPT (0.58) | MAPTPOLBSMN1; SMN2GPR6ACHE | |
| SCHEMBL2064195 | 0.83 | MAPT (0.76) | MAPTPOLBSMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL2854321 | 0.83 | MAPT (0.53) | MAPTPOLBSMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL10364984 | 0.83 | KEAP1 (0.46) | MAPTPOLBSMN1; SMN2KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |
| EP-0151866-B1 | HERBICIDAL PYRAZOLE-(THIO)-CARBOXAMIDES | ELI LILLY AND COMPANY (US) | 1990-07-25 | — | — | EP | disclosed |
| US-4620865-A | Herbicidal and algicidal 1,5-disubstituted-1H-pyrazole-4-carboxamides | ELI LILLY AND COMPANY (US) | 1986-11-04 | — | — | US | disclosed |
| EP-0151866-A2 | Herbicidal pyrazole-(thio)-carboxamides | ELI LILLY AND COMPANY (US) | 1985-08-21 | — | — | EP | disclosed |