SCHEMBL28544504

SCHEMBL28544504

NC(=O)O[C@H]1CCC[C@@H](Nc2cc(-c3ccccc3)nc(Cl)n2)C1

nearest known ligand 0.42

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
VCP P55072 4/20 0.42
ADORA1 P30542 8/20 0.42
ADORA2A P29274 6/20 0.42
ADORA3 P0DMS8 5/20 0.42
KMT2A Q03164 3/20 0.38
MEN1 O00255 2/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
ALDH1A1 P00352 1/20 0.38
HPGD P15428 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
CDC7 O00311 1/20 0.36
DBF4 Q9UBU7 1/20 0.36
CNR1 P21554 1/20 0.35
KDM4E B2RXH2 2/20 0.35
HTT P42858 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20576178 1.00 VCP (0.42) VCPADORA1ADORA2AADORA3KMT2A
SCHEMBL22986923 0.84 ADORA2A (0.38) ADORA1ADORA2AADORA3KMT2AMEN1
SCHEMBL20576629 0.82 ADORA1 (0.46) VCPADORA1ADORA2AADORA3KMT2A
SCHEMBL3229148 0.81 SMN1; SMN2 (0.54) VCPADORA1ADORA2AADORA3KMT2A
SCHEMBL30321182 0.80 PIM1 (0.46) VCPADORA1ADORA2AADORA3KMT2A
SCHEMBL28531382 0.80 PIM1 (0.46) VCPADORA1ADORA2AADORA3KMT2A
SCHEMBL3237770 0.78 SMN1; SMN2 (0.54) VCPADORA1ADORA2AADORA3KMT2A
SCHEMBL3450507 0.77 CDC7 (0.53) VCPADORA1ADORA2AADORA3KMT2A
SCHEMBL30321332 0.77 KMT2A (0.47) VCPADORA1ADORA2AADORA3KMT2A
SCHEMBL20576463 0.77 DPP7 (0.43) VCPADORA1ADORA2AADORA3SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109748915-B Inhibitors of influenza virus replication and methods of use and uses thereof 广东东阳光药业有限公司 2021-03-26 CN disclosed