SCHEMBL28545688

SCHEMBL28545688

Cc1ccc(-c2ccccc2)c(O)c1Cl

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR2 Q92731 1/20 0.50
HDAC4 P56524 1/20 0.44
HDAC2 Q92769 1/20 0.44
HDAC8 Q9BY41 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44
ELANE P08246 1/20 0.42
BACE1 P56817 1/20 0.41
ALOX5 P09917 1/20 0.41
CYP2A6 P11509 2/20 0.40
ALDH1A1 P00352 1/20 0.40
HPGD P15428 1/20 0.40
BCL2L1 Q07817 1/20 0.40
HSD17B10 Q99714 1/20 0.40
HNF4A P41235 1/20 0.40
CYP2B6 P20813 1/20 0.39
PDE4B Q07343 3/20 0.39
PDE4A P27815 2/20 0.39
PDE4C Q08493 2/20 0.39
PDE4D Q08499 2/20 0.39
MAOA P21397 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4470081 0.82 ESR2 (0.42) ESR2CYP2A6CYP2B6CTRC
SCHEMBL28963238 0.81 ESR2 (0.45) ESR2BACE1ALOX5CYP2A6ALDH1A1
SCHEMBL10617137 0.81 ESR2 (0.55) ESR2HDAC4HDAC2HDAC8HDAC6
SCHEMBL6423564 0.79 ESR2 (0.53) ESR2HDAC4HDAC2HDAC8HDAC6
SCHEMBL9469704 0.79 ESR2 (0.53) ESR2HDAC4HDAC2HDAC8HDAC6
SCHEMBL28152739 0.79 BACE1 (0.50) ESR2HDAC4HDAC2HDAC8HDAC6
SCHEMBL932320 0.79 CYP2A6 (0.48) ESR2HDAC4HDAC2HDAC8HDAC6
SCHEMBL11060541 0.79 ESR2 (0.44) ESR2BACE1ALOX5CYP2A6CYP2B6
Methane SCHEMBL28025030 0.79 ESR2 (0.53) ESR2HDAC4HDAC2HDAC8HDAC6
Methane SCHEMBL28112790 0.78 BACE1 (0.48) ESR2HDAC4HDAC2HDAC8HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112639052-A Material for organic electroluminescent device 默克专利有限公司 2021-04-09 CN disclosed