Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 4/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.38 |
| ▸ | SPHK1 | Q9NYA1 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12609268 | 0.78 | KCNH2 (0.53) | KCNH2 | |
| SCHEMBL17561037 | 0.77 | DNM2 (0.55) | KCNH2 | |
| SCHEMBL1231970 | 0.77 | KMT2A (0.49) | KCNH2 | |
| SCHEMBL1231968 | 0.77 | KCNH2 (0.44) | KCNH2SPHK1 | |
| SCHEMBL1257991 | 0.75 | NR3C2 (0.43) | NR3C2SPHK1 | |
| SCHEMBL11034761 | 0.75 | KDM4E (0.38) | NR3C2 | |
| SCHEMBL14340874 | 0.74 | NPC1 (0.41) | — | |
| SCHEMBL28551461 | 0.74 | KCNH2 (0.47) | KCNH2 | |
| SCHEMBL1028320 | 0.73 | KCNH3 (0.56) | KCNH2 | |
| SCHEMBL11565431 | 0.73 | MAP4K4 (0.50) | KCNH2SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112641787-A | Combination therapy comprising a B-Raf inhibitor and a second inhibitor | 诺华股份有限公司 | 2021-04-13 | — | — | CN | disclosed |