SCHEMBL28548328

SCHEMBL28548328

NC(=O)OC1CCC(C(=O)NNC(=O)C(F)F)CC1

nearest known ligand 0.36

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.33
ATM Q13315 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28548327 1.00 L3MBTL1 (0.33) L3MBTL1ATM
SCHEMBL28527216 0.74 ATM (0.36) ATM
SCHEMBL21733423 0.74 MAPT (0.50)
SCHEMBL28527217 0.74 ATM (0.36) ATM
SCHEMBL28909851 0.74 ATM (0.32) ATM
SCHEMBL28909852 0.74 ATM (0.32) ATM
SCHEMBL16335866 0.71 ATM (0.38) ATM
SCHEMBL21378960 0.71 POLB (0.48) L3MBTL1ATM
SCHEMBL16335867 0.71 ATM (0.38) ATM
SCHEMBL21680688 0.71 MAPT (0.40) L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112566915-A Thiadiazole IRAK4 inhibitor 吉利德科学公司 2021-03-26 CN disclosed
CN-112566697-A Pyrrolo [1,2-b ] pyridazine derivatives as IRAK4 inhibitors 吉利德科学公司 2021-03-26 CN disclosed
CN-112533924-A Pyrrolo [1,2-b ] pyridazine derivatives as IRAK4 inhibitors 吉利德科学公司 2021-03-19 CN disclosed