Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.43 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.43 |
| ▸ | HTR3B | O95264 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.43 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31381163 | 0.73 | NOTUM (0.70) | NOTUMPOLBHTR2CALDH1A1TSHR | |
| SCHEMBL3773773 | 0.73 | KDM4E (0.62) | POLBALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL34469814 | 0.73 | NOTUM (0.52) | NOTUMPOLBHTR2CHTR2AHTR2B | |
| Hydrochloric Acid SCHEMBL34469418 | 0.72 | NOTUM (0.68) | NOTUMPOLBHTR2CALDH1A1TSHR | |
| SCHEMBL3097846 | 0.67 | POLB (0.60) | NOTUMPOLBALDH1A1TSHRLMNA | |
| SCHEMBL27782378 | 0.67 | HTR2C (0.54) | NOTUMPOLBHTR2CHTR2AHTR2B | |
| SCHEMBL23777729 | 0.67 | NOTUM (0.54) | NOTUMPOLBALDH1A1TSHRLMNA | |
| SCHEMBL23777631 | 0.67 | NOTUM (0.54) | NOTUMPOLBALDH1A1TSHRLMNA | |
| SCHEMBL23777635 | 0.67 | NOTUM (0.54) | NOTUMPOLBALDH1A1TSHRLMNA | |
| SCHEMBL7768606 | 0.67 | LMNA (0.56) | POLBHTR2CALDH1A1TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |