Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | TSHR | P16473 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.54 |
| ▸ | HTR3B | O95264 | 1/20 | 0.54 |
| ▸ | HTR1D | P28221 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10294005 | 0.83 | ALDH1A1 (0.62) | LMNATSHRALDH1A1HTTNPSR1 | |
| SCHEMBL8691047 | 0.82 | LMNA (0.58) | LMNATSHRALDH1A1HTTNPSR1 | |
| SCHEMBL28226906 | 0.81 | ALDH1A1 (0.77) | LMNATSHRALDH1A1HTTNPSR1 | |
| SCHEMBL18701879 | 0.80 | LMNA (0.64) | LMNATSHRALDH1A1HTTNPSR1 | |
| SCHEMBL13923614 | 0.79 | LMNA (0.67) | LMNATSHRALDH1A1HTTNPSR1 | |
| SCHEMBL27896818 | 0.79 | LMNA (0.71) | LMNATSHRALDH1A1HTTNPSR1 | |
| SCHEMBL631027 | 0.77 | LMNA (0.70) | LMNATSHRALDH1A1HTTNPSR1 | |
| SCHEMBL30087641 | 0.77 | ADRA2C (0.53) | LMNATSHRALDH1A1HTTNPSR1 | |
| SCHEMBL31381163 | 0.77 | NOTUM (0.70) | LMNATSHRALDH1A1HTTNPSR1 | |
| SCHEMBL11278842 | 0.76 | SIGMAR1 (0.62) | LMNATSHRALDH1A1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104413-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOUNDS CONTAINING THEM | ELI LILLY AND COMPANY LIMITED (GB) | 2001-06-06 | — | — | EP | disclosed |
| WO-2000008006-A2 | PIPERIDINE AND PIPERAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOUNDS CONTAINING THEM | ELI LILLY AND COMPANY LIMITED (GB) | 2000-02-17 | — | — | WO | disclosed |