Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | GPR183 | P32249 | 1/20 | 0.42 |
| ▸ | APLNR | P35414 | 1/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | MST1R | Q04912 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2861123 | 0.94 | NPC1 (0.47) | S1PR1ADRB2GPR183APLNRS1PR5 | |
| SCHEMBL2861576 | 0.86 | MAPT (0.45) | ATMMETNPC1POLBMAPT | |
| SCHEMBL2848317 | 0.84 | MAPT (0.46) | ATMMETNPC1POLBMAPT | |
| SCHEMBL2860975 | 0.84 | MAPT (0.49) | ATMMETNPC1POLBMAPT | |
| SCHEMBL2856759 | 0.83 | ACLY (0.44) | ATMMETMST1RNPC1POLB | |
| SCHEMBL2852244 | 0.83 | MAPT (0.48) | ATMMETPOLBMAPTNPSR1 | |
| SCHEMBL2858311 | 0.83 | RAB9A (0.47) | ATMNPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL2858533 | 0.82 | ATM (0.47) | ATMMETNPC1RAB9AMAPT | |
| SCHEMBL2853154 | 0.81 | MAPT (0.44) | ATMMETMST1RPOLBMAPT | |
| SCHEMBL2850258 | 0.81 | MAPT (0.51) | MAPTNPSR1KDM4EHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |