Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.44 |
| ▸ | CPB2 | Q96IY4 | 7/20 | 0.37 |
| ▸ | CPB1 | P15086 | 3/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.35 |
| ▸ | ARG1 | P05089 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL23363055 | 1.00 | GSR (0.44) | GSRCPB2CPB1ITGB3ITGA2B | |
| Histidine SCHEMBL285636 | 0.94 | GSR (0.39) | GSRCPB2CPB1ITGB3ITGA2B | |
| Histidine SCHEMBL285814 | 0.92 | GSR (0.38) | GSRCPB2CPB1ITGB3ITGA2B | |
| Histidine SCHEMBL342892 | 0.92 | CYP3A4 (0.40) | CYP3A4SLC7A5ARG1CYP1A2 | |
| Histidine SCHEMBL27681989 | 0.92 | CYP3A4 (0.40) | CYP3A4SLC7A5ARG1CYP1A2 | |
| Histidine SCHEMBL342891 | 0.92 | CYP3A4 (0.40) | CYP3A4SLC7A5ARG1CYP1A2 | |
| Histidine SCHEMBL28650960 | 0.91 | CYP3A4 (0.40) | CYP3A4SLC7A5ARG1CYP1A2 | |
| Histidine SCHEMBL305855 | 0.91 | GSR (0.54) | GSRCPB2CPB1ITGB3ITGA2B | |
| Histidine SCHEMBL4297918 | 0.91 | GSR (0.54) | GSRCPB2CPB1ITGB3ITGA2B | |
| Histidine SCHEMBL305856 | 0.91 | GSR (0.54) | GSRCPB2CPB1ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3103446-A2 | PHARMACEUTICAL PREPARATION FOR PREVENTING AND TREATING PROGRESSIVE MYOPIA | Zakharov, Ivan Dmitrievich (RU) | 2016-12-14 | — | — | EP | claimed |
| US-20120135931-A1 | METHOD OF MODIFYING SERINE PROTEASE INHIBITORS | NATURAL ENVIRONMENT RESEARCH COUNCIL (GB) | 2012-05-31 | — | — | US | claimed |
| EP-2427487-A2 | METHOD OF MODIFYING SERINE PROTEASE INHIBITORS | Natural Environment Research Council (GB) | 2012-03-14 | — | — | EP | claimed |
| WO-2010128285-A2 | METHOD OF MODIFYING SERINE PROTEASE INHIBITORS | NATURAL ENVIRONMENT RESEARCH COUNCIL (GB) | 2010-11-11 | — | — | WO | claimed |
| EP-3103446-B1 | PHARMACEUTICAL PREPARATION FOR PREVENTING AND TREATING PROGRESSIVE MYOPIA | ZAKHAROV IVAN DMITRIEVICH (RU) | 2024-02-14 | — | — | EP | disclosed |
| EP-3131573-A1 | COMPOSITIONS COMPRISING VARIEGIN | University of Leeds (GB) | 2017-02-22 | — | — | EP | disclosed |
| US-20170035863-A1 | Compositions Comprising Variegin | UNIVERSITY OF LEEDS (GB) | 2017-02-09 | — | — | US | disclosed |
| EP-3103446-A2 | PHARMACEUTICAL PREPARATION FOR PREVENTING AND TREATING PROGRESSIVE MYOPIA | Zakharov, Ivan Dmitrievich (RU) | 2016-12-14 | — | — | EP | disclosed |
| WO-2015159084-A1 | COMPOSITIONS COMPRISING VARIEGIN | UNIVERSITY OF LEEDS (GB) | 2015-10-22 | — | — | WO | disclosed |
| US-20120135931-A1 | METHOD OF MODIFYING SERINE PROTEASE INHIBITORS | NATURAL ENVIRONMENT RESEARCH COUNCIL (GB) | 2012-05-31 | — | — | US | disclosed |
| EP-2427487-A2 | METHOD OF MODIFYING SERINE PROTEASE INHIBITORS | Natural Environment Research Council (GB) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128285-A2 | METHOD OF MODIFYING SERINE PROTEASE INHIBITORS | NATURAL ENVIRONMENT RESEARCH COUNCIL (GB) | 2010-11-11 | — | — | WO | disclosed |