Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.54 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | ARG1 | P05089 | 4/20 | 0.40 |
| ▸ | CPB2 | Q96IY4 | 3/20 | 0.40 |
| ▸ | CPB1 | P15086 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | ARG2 | P78540 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL28245493 | 1.00 | GSR (0.54) | GSRITGB3ITGA2BARG1CPB2 | |
| D-Histidine SCHEMBL902054 | 1.00 | GSR (0.54) | GSRITGB3ITGA2BARG1CPB2 | |
| Histidine SCHEMBL4294462 | 1.00 | GSR (0.54) | GSRITGB3ITGA2BARG1CPB2 | |
| Histidine SCHEMBL27440707 | 1.00 | GSR (0.54) | GSRITGB3ITGA2BARG1CPB2 | |
| Histidine SCHEMBL305856 | 1.00 | GSR (0.54) | GSRITGB3ITGA2BARG1CPB2 | |
| Histidine SCHEMBL16714200 | 1.00 | GSR (0.54) | GSRITGB3ITGA2BARG1CPB2 | |
| Histidine SCHEMBL4297918 | 1.00 | GSR (0.54) | GSRITGB3ITGA2BARG1CPB2 | |
| Histidine SCHEMBL27767215 | 1.00 | GSR (0.54) | GSRITGB3ITGA2BARG1CPB2 | |
| Histidine SCHEMBL18419548 | 1.00 | GSR (0.54) | GSRITGB3ITGA2BARG1CPB2 | |
| Histidine SCHEMBL4735217 | 0.99 | GSR (0.53) | GSRITGB3ITGA2BARG1CPB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 418 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3675814-A1 | COMPOSITION FOR TOPICAL TREATMENT OF NON-MICROORGANISM-CAUSED INFLAMMATORY SKIN AND MUCOUS-MEMBRANE DISEASES | Bläss, Markus (DE) | 2020-07-08 | — | — | EP | claimed |
| CN-109568594-A | Polycation macromolecular prodrug is used for the preparation and application of gene delivery, nano composite system | 南华大学 | 2019-04-05 | — | — | CN | claimed |
| US-20190025316-A1 | PROTEIN INTERACTOR DETECTION SYSTEMS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-01-24 | — | — | US | claimed |
| US-9951183-B2 | Amphiphilic blockcopolymers comprising reduction sensitive biodegradable polyesteramides | DSM IP ASSETS, B.V. (NL) | 2018-04-24 | — | — | US | claimed |
| US-20170218123-A1 | AMPHIPHILIC BLOCKCOPOLYMERS COMPRISING REDUCTION SENSITIVE BIODEGRADABLE POLYESTERAMIDES | DSM IP ASSETS, B.V. (NL) | 2017-08-03 | — | — | US | claimed |
| WO-2017123800-A1 | PROTEIN INTERACTOR DETECTION SYSTEMS | THE REGENTS OF UNIVERSITY OF CALIFORNIA (US) | 2017-07-20 | — | — | WO | claimed |
| CN-105960411-A | Self-assembling peptides, peptidomimetics and peptidic conjugates as building blocks for biofabrication and printing | 新加坡科技研究局 | 2016-09-21 | — | — | CN | claimed |
| CN-101812177-B | Preparations of cationic polymer modified by steroid hormone and gene composite thereof | UNIV CHINA PHARMA | 2012-01-25 | — | — | CN | claimed |
| US-20030215877-A1 | Directed protein docking algorithm | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2003-11-20 | — | — | US | claimed |
| WO-2003087310-A2 | DIRECTED PROTEIN DOCKING ALGORITHM | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2003-10-23 | — | — | WO | claimed |
| CN-1193278-A | Chemical compounds | ZENECA LTD (GB) | 1998-09-16 | — | — | CN | claimed |
| CN-118286454-A | Lipid polypeptide nano delivery system with core-shell structure | 圣诺生物医药技术(苏州)有限公司 | 2024-07-05 | — | — | CN | disclosed |
| US-12006500-B2 | Composition and methods of RNAi prophylactics and therapeutics for treatment of severe acute respiratory infection caused by 2019 novel coronavirus (2019-nCoV) | SIRNAOMICS, INC. (US) | 2024-06-11 | — | — | US | disclosed |
| US-20240158794-A1 | NUCLEOSIDE CONTAINING siRNAS FOR TREATING VIRAL DISEASES | SIRNAOMICS, INC. | 2024-05-16 | — | — | US | disclosed |
| CN-114671912-B | Method for homogeneously synthesizing blue copper tripeptide with assistance of light shearing carrier | 西北工业大学 | 2024-05-14 | — | — | CN | disclosed |
| WO-1998024907-A1 | NOVEL PROTEIN WITH CHEMOKINE ACTIVITY | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |
| WO-1998016644-A1 | FIBROBLAST GROWTH FACTOR HOMOLOGS | ZYMOGENETICS, INC. (US) | 1998-04-23 | — | — | WO | disclosed |
| WO-1998009991-A2 | ENTERIC NEURAL PEPTIDE | ZYMOGENETICS, INC. (US) | 1998-03-12 | — | — | WO | disclosed |
| WO-1997043412-A1 | NOVEL AGOUTI-RELATED GENE | AMGEN INC. (US) | 1997-11-20 | — | — | WO | disclosed |
| CN-1042821-A | The production method of paddy plumule nutritious drink goods | SHANGHAI INST OF CEREAL SCIENC (CN) | 1990-06-13 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240158794-A1 | NUCLEOSIDE CONTAINING siRNAS FOR TREATING VIRAL DISEASES | ADAR, SAMHD1, RNASE1 | GSR 2578/4885ITGB3 2204/4885ITGA2B 2924/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.