Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1005396 | 1.00 | MEN1 (0.38) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL11779333 | 1.00 | MEN1 (0.38) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL14655773 | 1.00 | MEN1 (0.38) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL28553406 | 1.00 | MEN1 (0.38) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL7713157 | 1.00 | MEN1 (0.38) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL11782151 | 0.97 | MEN1 (0.34) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL2146763 | 0.92 | ALDH1A1 (0.39) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL95923 | 0.92 | ALDH1A1 (0.39) | MEN1THRBHTTKMT2AMAPT | |
| SCHEMBL355712 | 0.90 | — | — | |
| SCHEMBL3801559 | 0.90 | CYP3A4 (0.34) | MEN1THRBHTTKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112724088-A | Uracil compound and anti-tumor application thereof | 中国医学科学院医药生物技术研究所 | 2021-04-30 | — | — | CN | claimed |
| CN-112618550-A | Antineoplastic uracil compound and lipid composition thereof | 中国医学科学院医药生物技术研究所 | 2021-04-09 | — | — | CN | claimed |
| CN-112724088-B | Uracil compound and anti-tumor application thereof | 中国医学科学院医药生物技术研究所 | 2022-04-29 | — | — | CN | disclosed |
| CN-112724088-A | Uracil compound and anti-tumor application thereof | 中国医学科学院医药生物技术研究所 | 2021-04-30 | — | — | CN | disclosed |
| CN-112618550-A | Antineoplastic uracil compound and lipid composition thereof | 中国医学科学院医药生物技术研究所 | 2021-04-09 | — | — | CN | disclosed |