Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.65 |
| ▸ | DAO | P14920 | 1/20 | 0.65 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.61 |
| ▸ | CES2 | O00748 | 3/20 | 0.61 |
| ▸ | CES1 | P23141 | 3/20 | 0.61 |
| ▸ | TPMT | P51580 | 1/20 | 0.56 |
| ▸ | RXRA | P19793 | 1/20 | 0.56 |
| ▸ | RXRB | P28702 | 1/20 | 0.56 |
| ▸ | RXRG | P48443 | 1/20 | 0.56 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA3 | P07451 | 1/20 | 0.52 |
| ▸ | TYR | P14679 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL29395194 | 1.00 | TSHR (0.65) | TSHRDAONAPRTALDH1A1SMN1; SMN2 | |
| Terephthalic Acid SCHEMBL9341320 | 1.00 | TSHR (0.65) | TSHRDAONAPRTALDH1A1SMN1; SMN2 | |
| Benzoic Acid SCHEMBL28919560 | 0.95 | TSHR (0.74) | TSHRDAONAPRTALDH1A1SMN1; SMN2 | |
| Benzoic Acid SCHEMBL3897338 | 0.95 | TSHR (0.74) | TSHRDAONAPRTALDH1A1SMN1; SMN2 | |
| Terephthalic Acid SCHEMBL27877780 | 0.93 | ALDH1A1 (0.77) | TSHRDAONAPRTALDH1A1SMN1; SMN2 | |
| Terephthalic Acid SCHEMBL28419061 | 0.87 | SMN1; SMN2 (0.56) | TSHRDAONAPRTALDH1A1SMN1; SMN2 | |
| Benzoic Acid SCHEMBL29130879 | 0.84 | CES2 (0.71) | TSHRDAONAPRTALDH1A1SMN1; SMN2 | |
| O-Xylene SCHEMBL10750289 | 0.84 | KDM4E (0.58) | TSHRDAONAPRTALDH1A1SMN1; SMN2 | |
| Terephthalic Acid SCHEMBL27797198 | 0.84 | TDP1 (0.60) | TSHRDAONAPRTALDH1A1SMN1; SMN2 | |
| Terephthalic Acid SCHEMBL28195120 | 0.84 | ALDH1A1 (0.80) | TSHRDAONAPRTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115279590-A | Use of colour effect pigments for enhancing the infrared absorption capacity of coloured polymers | 默克专利股份有限公司 | 2022-11-01 | — | — | CN | disclosed |
| CN-109152469-B | Tooth brush | 狮王株式会社 | 2021-03-05 | — | — | CN | disclosed |