Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 3/20 | 0.43 |
| ▸ | MAOB | P27338 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | AMPD2 | Q01433 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2699801 | 0.87 | SPHK1 (0.49) | SPHK1MAOAMAOBCYP2C19 | |
| SCHEMBL14142405 | 0.85 | GAA (0.46) | KDM4ESPHK1MAOAMAOBDRD4 | |
| SCHEMBL7309417 | 0.82 | SPHK1 (0.63) | KDM4ESPHK1MAOAMAOBTDP1 | |
| SCHEMBL6501382 | 0.81 | KMT2A (0.54) | KDM4ESPHK1KMT2AMAOAMAOB | |
| SCHEMBL6505049 | 0.81 | FAAH (0.48) | SPHK1KMT2AMAOAMAOB | |
| SCHEMBL4704664 | 0.79 | GBA1 (0.40) | KDM4ESPHK1SIGMAR1KMT2AMAOA | |
| SCHEMBL2852932 | 0.79 | MAOB (0.47) | SPHK1MAOAMAOB | |
| SCHEMBL4592233 | 0.79 | SPHK1 (0.40) | KDM4ESPHK1SIGMAR1KMT2AMAOA | |
| SCHEMBL5015327 | 0.78 | KDM4E (0.48) | KDM4ESIGMAR1DRD4MAPT | |
| SCHEMBL6504152 | 0.77 | CCR8 (0.52) | SPHK1KMT2AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |