Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.51 |
| ▸ | CCR8 | P51685 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6504152 | 0.88 | CCR8 (0.52) | KMT2AMEN1SPHK1CCR8MAOB | |
| SCHEMBL6505049 | 0.87 | FAAH (0.48) | KMT2AMEN1SPHK1CCR8FAAH | |
| SCHEMBL2699801 | 0.85 | SPHK1 (0.49) | SPHK1GAASMN1; SMN2POLBMAOA | |
| SCHEMBL6505185 | 0.83 | CCR8 (0.45) | KMT2AMEN1SPHK1CCR8ALDH1A1 | |
| SCHEMBL2855574 | 0.81 | KDM4E (0.46) | KMT2ASPHK1KDM4ETDP1MAOA | |
| SCHEMBL14813948 | 0.75 | GRM2 (0.46) | KMT2AMEN1ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL3873308 | 0.74 | ALDH1A1 (0.42) | SPHK1ALDH1A1TDP1POLBMAOA | |
| SCHEMBL14142405 | 0.74 | GAA (0.46) | SPHK1ALDH1A1KDM4EGAAPOLB | |
| SCHEMBL5015327 | 0.74 | KDM4E (0.48) | ALDH1A1KDM4EHTTPOLB | |
| SCHEMBL4891642 | 0.74 | KMT2A (0.55) | KMT2AMEN1CCR8ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050143372-A1 | Compounds, pharmaceutical compositions and methods of use therefor | MILLENNIUM PHARMACEUTICALS, INC. | 2005-06-30 | — | — | US | disclosed |
| WO-2003037271-A2 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREFOR | MILLENNIUM PHARMACEUTICALS,INC. (US) | 2003-05-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143372-A1 | Compounds, pharmaceutical compositions and methods of use therefor | CCR8, CCL11, CCR5 | KMT2A 4477/4885MEN1 3088/4885SPHK1 541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.