Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL286461 | 1.00 | KMT2A (0.47) | KMT2AMEN1GAATP53PLK1 | |
| SCHEMBL285570 | 1.00 | KMT2A (0.47) | KMT2AMEN1GAATP53PLK1 | |
| SCHEMBL286110 | 0.90 | ALPL (0.48) | KMT2AMEN1GAAPOLBCASP6 | |
| SCHEMBL286109 | 0.90 | ALPL (0.48) | KMT2AMEN1GAAPOLBCASP6 | |
| SCHEMBL286177 | 0.86 | ADORA3 (0.55) | KMT2AMEN1GAATP53HDAC6 | |
| SCHEMBL286445 | 0.86 | ADORA3 (0.55) | KMT2AMEN1GAATP53HDAC6 | |
| SCHEMBL286023 | 0.86 | ADORA3 (0.55) | KMT2AMEN1GAATP53HDAC6 | |
| SCHEMBL286178 | 0.84 | HDAC6 (0.46) | KMT2AMEN1GAATP53HDAC6 | |
| SCHEMBL285881 | 0.81 | KDM4E (0.43) | KMT2AMEN1GAATP53POLB | |
| SCHEMBL285882 | 0.81 | KDM4E (0.43) | KMT2AMEN1GAATP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427455-A1 | ISOXAZOLE-PYRAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010127975-A1 | ISOXAZOLE-PYRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-11-11 | — | — | WO | disclosed |