Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 9/20 | 0.50 |
| ▸ | NTRK2 | Q16620 | 9/20 | 0.50 |
| ▸ | IGF1R | P08069 | 4/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.50 |
| ▸ | NTRK3 | Q16288 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28549764 | 0.89 | NTRK1 (0.62) | NTRK1NTRK2IGF1RFGFR1NTRK3 | |
| SCHEMBL28397645 | 0.79 | LMNA (0.47) | NTRK1NTRK2IGF1RFGFR1NTRK3 | |
| SCHEMBL21295325 | 0.78 | NTRK1 (0.81) | NTRK1NTRK2IGF1RFGFR1NTRK3 | |
| SCHEMBL30743934 | 0.78 | NTRK1 (0.81) | NTRK1NTRK2IGF1RFGFR1NTRK3 | |
| SCHEMBL8472583 | 0.77 | NTRK1 (0.57) | NTRK1NTRK2IGF1RFGFR1NTRK3 | |
| SCHEMBL28398126 | 0.77 | NTRK1 (0.45) | NTRK1NTRK2IGF1RFGFR1NTRK3 | |
| SCHEMBL28402166 | 0.77 | NTRK1 (0.45) | NTRK1NTRK2IGF1RFGFR1NTRK3 | |
| SCHEMBL23292598 | 0.75 | NTRK1 (0.40) | NTRK1NTRK2IGF1RFGFR1NTRK3 | |
| SCHEMBL21305379 | 0.74 | NTRK1 (0.46) | NTRK1NTRK2IGF1RFGFR1NTRK3 | |
| SCHEMBL23292683 | 0.72 | NTRK1 (0.55) | NTRK1NTRK2IGF1RFGFR1NTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112703187-A | 4-substituted phenyl-1, 3, 5-triazine derivatives as modulators of TRK receptors | 阿泽克制药公司 | 2021-04-23 | — | — | CN | disclosed |