SCHEMBL8472583

SCHEMBL8472583

Cn1c(=O)[nH]c(=O)n(-c2ccccc2)c1=O

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NTRK1 P04629 9/20 0.57
NTRK2 Q16620 9/20 0.57
IGF1R P08069 5/20 0.57
FGFR1 P11362 5/20 0.57
NTRK3 Q16288 5/20 0.57
GSK3A P49840 3/20 0.53
GSK3B P49841 3/20 0.53
GAA P10253 1/20 0.50
PGR P06401 1/20 0.50
DDB1 Q16531 1/20 0.48
CRBN Q96SW2 1/20 0.48
MAPK1 P28482 1/20 0.46
MEN1 O00255 2/20 0.45
KMT2A Q03164 2/20 0.45
HSD17B10 Q99714 2/20 0.42
TSHR P16473 1/20 0.42
CYP2C19 P33261 1/20 0.42
LMNA P02545 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
GFER P55789 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5198556 0.86 NTRK1 (0.72) NTRK1NTRK2IGF1RFGFR1NTRK3
SCHEMBL11831354 0.85 NTRK1 (0.77) NTRK1NTRK2IGF1RFGFR1NTRK3
SCHEMBL11768132 0.84 NTRK1 (0.47) NTRK1NTRK2IGF1RFGFR1NTRK3
SCHEMBL8472767 0.81 NTRK1 (0.42) NTRK1NTRK2IGF1RFGFR1NTRK3
SCHEMBL28558142 0.77 NTRK1 (0.50) NTRK1NTRK2IGF1RFGFR1NTRK3
SCHEMBL5199351 0.77 GSK3B (0.71) GSK3AGSK3BGAAPGRMAPK1
SCHEMBL11728147 0.77 NTRK1 (0.57) NTRK1NTRK2IGF1RFGFR1NTRK3
SCHEMBL21305379 0.77 NTRK1 (0.46) NTRK1NTRK2IGF1RFGFR1NTRK3
SCHEMBL11684045 0.77 PGR (0.54) NTRK1NTRK2IGF1RFGFR1NTRK3
SCHEMBL11684638 0.77 NTRK1 (0.53) NTRK1NTRK2IGF1RFGFR1NTRK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5872253-A MULTISTAGE PROCESS WITH REACTION OF ISOTHIOCYANATE WITH AMINE AND CYCLIZATION THE THIOUREA WITH HALOCARBONYL HALIDE AMERICAN CYANAMID COMPANY (US) 1999-02-16 US disclosed
US-5726126-A 1-(3-heterocyclyphenyl)-S-triazine-2,6,6-oxo or thiotrione herbicidal agents AMERICAN CYANAMID COMPANY (US) 1998-03-10 US disclosed
US-5705644-A 1-(3-heterocyclphenyl)-s-triazine-2,4,6-oxo or thiotrione herbicidal agents AMERICAN CYANAMID COMPANY (US) 1998-01-06 US disclosed
US-5679791-A FROM A CORRESPONDING ISOTHIOCYANATE COMPOUNDS AND A HYDRAZINE COMPOUND AMERICAN CYANAMID COMPANY (US) 1997-10-21 US disclosed
US-5659031-A CONTROLLING WEEDS IN CROPS AMERICAN CYANAMID COMPANY (US) 1997-08-19 US disclosed
US-5616706-A PREEMERGENCE OR POSTEMERGENCE AMERICAN CYANAMID COMPANY (US) 1997-04-01 US disclosed
US-5612481-A 1-(3-heterocyclylphenyl)-s-triazine-2,4,6-oxo or thiortione herbicidal agents AMERICAN CYANAMID COMPANY (US) 1997-03-18 US disclosed
US-5610120-A APPLYING COMPOUND TO FOLIAGE OF UNDESIRABLE PLANTS OR TO THE SOIL OR WATER CONTAINING SEEDS THEREOF AMERICAN CYANAMID COMPANY (US) 1997-03-11 US disclosed
US-4056527-A HERBICIDE BAYER AKTIENGESELLSCHAFT (DT) 1977-11-01 US disclosed