Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 5/20 | 0.45 |
| ▸ | FYN | P06241 | 3/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.42 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.41 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.41 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.41 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.41 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.41 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.41 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.39 |
| ▸ | USP7 | Q93009 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30730821 | 0.83 | CHEK2 (0.54) | MAP4K4FYNTGFBR1ACVR1USP7 | |
| SCHEMBL22553850 | 0.83 | CHEK2 (0.54) | MAP4K4FYNTGFBR1ACVR1USP7 | |
| SCHEMBL28559252 | 0.82 | NPC1 (0.45) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL22553863 | 0.81 | NPC1 (0.48) | FYNPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL28560200 | 0.77 | CCNC (0.43) | TGFBR1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL22554202 | 0.76 | PRKAB2 (0.41) | MAP4K4FYNTGFBR1PRKAB2PRKAG1 | |
| SCHEMBL30730794 | 0.76 | PRKAB2 (0.41) | MAP4K4FYNTGFBR1PRKAB2PRKAG1 | |
| SCHEMBL22554034 | 0.75 | BRD4 (0.44) | MAP4K4FYNTGFBR1PRKAB2PRKAG1 | |
| SCHEMBL22553778 | 0.75 | TGFBR1 (0.36) | MAP4K4FYNTGFBR1PRKAB2PRKAG1 | |
| SCHEMBL30730809 | 0.75 | TGFBR1 (0.36) | MAP4K4FYNTGFBR1PRKAB2PRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112088157-A | Aryl-bipyridine amine derivatives as phosphoinositide kinase inhibitors | 拉文纳制药公司 | 2020-12-15 | — | — | CN | claimed |
| CN-112088157-A | Aryl-bipyridine amine derivatives as phosphoinositide kinase inhibitors | 拉文纳制药公司 | 2020-12-15 | — | — | CN | disclosed |