Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TLR4 | O00206 | 1/20 | 0.42 |
| ▸ | TLR2 | O60603 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.40 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.39 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.39 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20535670 | 0.93 | TLR4 (0.45) | HPGDMAPTPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL9700336 | 0.83 | PRMT5 (0.43) | HPGDMAPTPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL26977909 | 0.78 | MAPT (0.47) | HPGDMAPTPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL26162631 | 0.78 | ALDH1A1 (0.50) | HPGDMAPTPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL3803035 | 0.78 | NPC1 (0.64) | HPGDMAPTPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL31053714 | 0.77 | MAPT (0.46) | HPGDMAPTPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL30286782 | 0.75 | MAPT (0.44) | HPGDMAPTPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL10502417 | 0.75 | RECQL (0.46) | HPGDMAPTSMN1; SMN2ALDH1A1TLR4 | |
| SCHEMBL4928212 | 0.75 | MAPT (0.55) | HPGDMAPTPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL10532607 | 0.75 | MAPT (0.44) | HPGDMAPTPOLBSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112745237-B | 2-arylamine compound and preparation method and application thereof | 中国科学院上海药物研究所 | 2023-06-20 | — | — | CN | disclosed |
| CN-112745237-A | 2-arylamine compound and preparation method and application thereof | 中国科学院上海药物研究所 | 2021-05-04 | — | — | CN | disclosed |